ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

28S ribosomal protein S6, mitochondrial

Intermolecular
Cysteine 105 and cysteine 69 of 28S ribosomal protein S18c, mitochondrial L
Cysteine 105 and cysteine 101 of 28S ribosomal protein S18c, mitochondrial L
Cysteine 105 and cysteine 66 of 28S ribosomal protein S18c, mitochondrial L
A redox-regulated disulphide may form between cysteine 105 of 28S ribosomal protein S6, mitochondrial and cysteine 69 of 28S ribosomal protein S18c, mitochondrial.

Details

Redox score ?
74
PDB code
6neq
Structure name
structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit-class-ii
Structure deposition date
2018-12-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
14
Peptide A name
28S ribosomal protein S6, mitochondrial
Peptide B name
28S ribosomal protein S18c, mitochondrial
Peptide A accession
P82931
Peptide B accession
P82917
Peptide A residue number
105
Peptide B residue number
69

Ligandability

Cysteine 105 of 28S ribosomal protein S6, mitochondrial

Cysteine 69 of 28S ribosomal protein S18c, mitochondrial

A redox-regulated disulphide may form between cysteine 105 of 28S ribosomal protein S6, mitochondrial and cysteine 101 of 28S ribosomal protein S18c, mitochondrial.

Details

Redox score ?
70
PDB code
6nf8
Structure name
structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit -class i
Structure deposition date
2018-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
28
Peptide A name
28S ribosomal protein S6, mitochondrial
Peptide B name
28S ribosomal protein S18c, mitochondrial
Peptide A accession
P82931
Peptide B accession
P82917
Peptide A residue number
105
Peptide B residue number
101

Ligandability

Cysteine 105 of 28S ribosomal protein S6, mitochondrial

Cysteine 101 of 28S ribosomal protein S18c, mitochondrial

A redox-regulated disulphide may form between cysteine 105 of 28S ribosomal protein S6, mitochondrial and cysteine 66 of 28S ribosomal protein S18c, mitochondrial.

Details

Redox score ?
64
PDB code
6neq
Structure name
structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit-class-ii
Structure deposition date
2018-12-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
34
Peptide A name
28S ribosomal protein S6, mitochondrial
Peptide B name
28S ribosomal protein S18c, mitochondrial
Peptide A accession
P82931
Peptide B accession
P82917
Peptide A residue number
105
Peptide B residue number
66

Ligandability

Cysteine 105 of 28S ribosomal protein S6, mitochondrial

Cysteine 66 of 28S ribosomal protein S18c, mitochondrial

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