a tool for identifying drug-targetable redox-active disulphides

Thioredoxin-like protein 4A

Intramolecular

Cysteine 38 and cysteine 79

A redox-regulated disulphide may form within Thioredoxin-like protein 4A between cysteines 38 and 79.

Details

Redox score ?

76

PDB code

Structure name

crystal structure of the heterotrimer of pqbp1, u5-15kd and u5-52kd

Structure deposition date

2013-07-04

Thiol separation (Å)

4

Half-sphere exposure sum ?

65

Minimum pK_a ?

8

% buried

61

Peptide accession

Residue number A

38

Residue number B

79

Peptide name

Thioredoxin-like protein 4A

Ligandability

Cysteine 38 of Thioredoxin-like protein 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Thioredoxin-like protein 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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