ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ADP-ribosylation factor 1

Intermolecular
Cysteine 159 and cysteine 159
Intramolecular
Cysteine 22 and cysteine 42
A redox-regulated disulphide may form between two units of ADP-ribosylation factor 1 at cysteines 159 and 159 (289 and 289 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
3o47
Structure name
crystal structure of arfgap1-arf1 fusion protein
Structure deposition date
2010-07-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
54
Peptide A name
ADP-ribosylation factor 1
Peptide B name
ADP-ribosylation factor 1
Peptide A accession
P84077
Peptide B accession
P84077
Peptide A residue number
159
Peptide B residue number
159

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ADP-ribosylation factor 1 between cysteines 22 and 42.

Details

Redox score ?
nan
PDB code
3o47
Structure name
crystal structure of arfgap1-arf1 fusion protein
Structure deposition date
2010-07-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
3
% buried
44
Peptide accession
P84077
Residue number A
22
Residue number B
42
Peptide name
ADP-ribosylation factor 1

Ligandability

Cysteine 22 of ADP-ribosylation factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 42 of ADP-ribosylation factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 22 in protein A could not be asigned to a Uniprot residue.
Cysteine 42 in protein B could not be asigned to a Uniprot residue.
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