ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Enhancer of rudimentary homolog

Intramolecular
Cysteine 28 and cysteine 69
Cysteine 28 and cysteine 33
A redox-regulated disulphide may form within Enhancer of rudimentary homolog between cysteines 28 and 69.

Details

Redox score ?
62
PDB code
7cnc
Structure name
cystal structure of human erh in complex with dgcr8
Structure deposition date
2020-07-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
67
Peptide accession
P84090
Residue number A
28
Residue number B
69
Peptide name
Enhancer of rudimentary homolog

Ligandability

Cysteine 28 of Enhancer of rudimentary homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 69 of Enhancer of rudimentary homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Enhancer of rudimentary homolog between cysteines 28 and 33. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
2nml
Structure name
crystal structure of hef2/erh at 1
Structure deposition date
2006-10-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
62
Peptide accession
P84090
Residue number A
28
Residue number B
33
Peptide name
Enhancer of rudimentary homolog

Ligandability

Cysteine 28 of Enhancer of rudimentary homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 of Enhancer of rudimentary homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: