ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine/arginine-rich splicing factor 3

Intramolecular
Cysteine 72 and cysteine 74
Cysteine 6 and cysteine 10
A redox-regulated disulphide may form within Serine/arginine-rich splicing factor 3 between cysteines 72 and 74 (136 and 138 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2i2y
Structure name
solution structure of the rrm of srp20 bound to the rna cauc
Structure deposition date
2006-08-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
4
Peptide accession
P84103
Residue number A
72
Residue number B
74
Peptide name
Serine/arginine-rich splicing factor 3

Ligandability

Cysteine 72 of Serine/arginine-rich splicing factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of Serine/arginine-rich splicing factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine/arginine-rich splicing factor 3 between cysteines 6 and 10 (70 and 74 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2i38
Structure name
solution structure of the rrm of srp20
Structure deposition date
2006-08-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
6
Peptide accession
P84103
Residue number A
6
Residue number B
10
Peptide name
Serine/arginine-rich splicing factor 3

Ligandability

Cysteine 6 of Serine/arginine-rich splicing factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 10 of Serine/arginine-rich splicing factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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