ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Tumor necrosis factor-inducible gene 6 protein

Intramolecular
Cysteine 188 and cysteine 210
Cysteine 82 and cysteine 103
Cysteine 135 and cysteine 161
Cysteine 58 and cysteine 127
A redox-regulated disulphide may form within Tumor necrosis factor-inducible gene 6 protein between cysteines 188 and 210.

Details

Redox score ?
88
PDB code
2wno
Structure name
x-ray structure of cub_c domain from tsg-6
Structure deposition date
2009-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P98066
Residue number A
188
Residue number B
210
Peptide name
Tumor necrosis factor-inducible gene 6 protein

Ligandability

Cysteine 188 of Tumor necrosis factor-inducible gene 6 protein

Cysteine 210 of Tumor necrosis factor-inducible gene 6 protein

A redox-regulated disulphide may form within Tumor necrosis factor-inducible gene 6 protein between cysteines 82 and 103 (47 and 68 respectively in this structure).

Details

Redox score ?
86
PDB code
2pf5
Structure name
crystal structure of the human tsg-6 link module
Structure deposition date
2007-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P98066
Residue number A
82
Residue number B
103
Peptide name
Tumor necrosis factor-inducible gene 6 protein

Ligandability

Cysteine 82 of Tumor necrosis factor-inducible gene 6 protein

Cysteine 103 of Tumor necrosis factor-inducible gene 6 protein

A redox-regulated disulphide may form within Tumor necrosis factor-inducible gene 6 protein between cysteines 135 and 161.

Details

Redox score ?
86
PDB code
2wno
Structure name
x-ray structure of cub_c domain from tsg-6
Structure deposition date
2009-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P98066
Residue number A
135
Residue number B
161
Peptide name
Tumor necrosis factor-inducible gene 6 protein

Ligandability

Cysteine 135 of Tumor necrosis factor-inducible gene 6 protein

Cysteine 161 of Tumor necrosis factor-inducible gene 6 protein

A redox-regulated disulphide may form within Tumor necrosis factor-inducible gene 6 protein between cysteines 58 and 127 (23 and 92 respectively in this structure).

Details

Redox score ?
83
PDB code
2pf5
Structure name
crystal structure of the human tsg-6 link module
Structure deposition date
2007-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P98066
Residue number A
58
Residue number B
127
Peptide name
Tumor necrosis factor-inducible gene 6 protein

Ligandability

Cysteine 58 of Tumor necrosis factor-inducible gene 6 protein

Cysteine 127 of Tumor necrosis factor-inducible gene 6 protein

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