S-adenosylmethionine synthase isoform type-1
Intermolecular
Cysteine 68 and cysteine 60
Cysteine 34 and cysteine 68
Intramolecular
Cysteine 35 and cysteine 61
Cysteine 60 and cysteine 104
Cysteine 150 and cysteine 312
Cysteine 56 and cysteine 68
Cysteine 35 and cysteine 69
Cysteine 34 and cysteine 56
6sw6 A 68 B 60
A redox-regulated disulphide may form between two units of S-adenosylmethionine synthase isoform type-1 at cysteines 68 and 60. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
6sw6
Structure name
crystal structure r264h mutant of the human s-adenosylmethionine synthetase 1
Structure deposition date
2019-09-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
8
% buried
88
Peptide A name
S-adenosylmethionine synthase isoform type-1
Peptide B name
S-adenosylmethionine synthase isoform type-1
Peptide A accession
Q00266
Peptide B accession
Q00266
Peptide A residue number
68
Peptide B residue number
60
Ligandability
Cysteine 68 of S-adenosylmethionine synthase isoform type-1
Cysteine 60 of S-adenosylmethionine synthase isoform type-1
6sw6 A 34 B 68
A redox-regulated disulphide may form between two units of S-adenosylmethionine synthase isoform type-1 at cysteines 34 and 68. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
6sw6
Structure name
crystal structure r264h mutant of the human s-adenosylmethionine synthetase 1
Structure deposition date
2019-09-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
92
Peptide A name
S-adenosylmethionine synthase isoform type-1
Peptide B name
S-adenosylmethionine synthase isoform type-1
Peptide A accession
Q00266
Peptide B accession
Q00266
Peptide A residue number
34
Peptide B residue number
68
Ligandability
Cysteine 34 of S-adenosylmethionine synthase isoform type-1
Cysteine 68 of S-adenosylmethionine synthase isoform type-1
1o90 B 35 B 61
A redox-regulated disulphide may form within S-adenosylmethionine synthase isoform type-1 between cysteines 35 and 61.
Details
Redox score ?
70
PDB code
1o90
Structure name
methionine adenosyltransferase complexed with a l-methionine analogue
Structure deposition date
2002-12-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
9
% buried
100
Peptide accession
P13444
Residue number A
35
Residue number B
61
Peptide name
S-adenosylmethionine synthase isoform type-1
Ligandability
Cysteine 35 of S-adenosylmethionine synthase isoform type-1
Cysteine 61 of S-adenosylmethionine synthase isoform type-1
6sw6 B 60 B 104
A redox-regulated disulphide may form within S-adenosylmethionine synthase isoform type-1 between cysteines 60 and 104. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
6sw6
Structure name
crystal structure r264h mutant of the human s-adenosylmethionine synthetase 1
Structure deposition date
2019-09-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
73
Peptide accession
Q00266
Residue number A
60
Residue number B
104
Peptide name
S-adenosylmethionine synthase isoform type-1
Ligandability
Cysteine 60 of S-adenosylmethionine synthase isoform type-1
Cysteine 104 of S-adenosylmethionine synthase isoform type-1
1qm4 A 150 A 312
A redox-regulated disulphide may form within S-adenosylmethionine synthase isoform type-1 between cysteines 150 and 312. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
1qm4
Structure name
methionine adenosyltransferase complexed with a l-methionine analogue
Structure deposition date
1999-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
78
Peptide accession
P13444
Residue number A
150
Residue number B
312
Peptide name
S-adenosylmethionine synthase isoform type-1
Ligandability
Cysteine 150 of S-adenosylmethionine synthase isoform type-1
Cysteine 312 of S-adenosylmethionine synthase isoform type-1
6sw6 A 56 A 68
A redox-regulated disulphide may form within S-adenosylmethionine synthase isoform type-1 between cysteines 56 and 68. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6sw6
Structure name
crystal structure r264h mutant of the human s-adenosylmethionine synthetase 1
Structure deposition date
2019-09-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
88
Peptide accession
Q00266
Residue number A
56
Residue number B
68
Peptide name
S-adenosylmethionine synthase isoform type-1
Ligandability
Cysteine 56 of S-adenosylmethionine synthase isoform type-1
Cysteine 68 of S-adenosylmethionine synthase isoform type-1
1qm4 A 35 A 69
A redox-regulated disulphide may form within S-adenosylmethionine synthase isoform type-1 between cysteines 35 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
24
PDB code
1qm4
Structure name
methionine adenosyltransferase complexed with a l-methionine analogue
Structure deposition date
1999-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
90
Peptide accession
P13444
Residue number A
35
Residue number B
69
Peptide name
S-adenosylmethionine synthase isoform type-1
Ligandability
Cysteine 35 of S-adenosylmethionine synthase isoform type-1
Cysteine 69 of S-adenosylmethionine synthase isoform type-1
2obv A 34 A 56
A redox-regulated disulphide may form within S-adenosylmethionine synthase isoform type-1 between cysteines 34 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
23
PDB code
2obv
Structure name
crystal structure of the human s-adenosylmethionine synthetase 1 in complex with the product
Structure deposition date
2006-12-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
98
Peptide accession
Q00266
Residue number A
34
Residue number B
56
Peptide name
S-adenosylmethionine synthase isoform type-1
Ligandability
Cysteine 34 of S-adenosylmethionine synthase isoform type-1
Cysteine 56 of S-adenosylmethionine synthase isoform type-1
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