a tool for identifying drug-targetable redox-active disulphides

Cyclin-dependent kinase 5

Intermolecular

Cysteine 53 and cysteine 261 of Cyclin-dependent kinase 5 activator 1

A redox-regulated disulphide may form between cysteine 53 of Cyclin-dependent kinase 5 and cysteine 261 of Cyclin-dependent kinase 5 activator 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

30

PDB code

Structure name

the structure of cyclin-dependent kinase 5 (cdk5) in complex with p25 and compound 7

Structure deposition date

2021-09-07

Thiol separation (Å)

9

Half-sphere exposure sum ?

77

Minimum pK_a ?

12

% buried

100

Peptide A name

Cyclin-dependent kinase 5

Peptide B name

Cyclin-dependent kinase 5 activator 1

Peptide A accession

Peptide B accession

Peptide A residue number

53

Peptide B residue number

261

Ligandability

Cysteine 53 of Cyclin-dependent kinase 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of Cyclin-dependent kinase 5 activator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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