Norrin
Intermolecular
Cysteine 131 and cysteine 131
Cysteine 93 and cysteine 93
Cysteine 93 and cysteine 69
Cysteine 95 and cysteine 95
Cysteine 93 and cysteine 128
Cysteine 93 and cysteine 96
Cysteine 93 and cysteine 39
Intramolecular
Cysteine 55 and cysteine 110
Cysteine 69 and cysteine 128
Cysteine 39 and cysteine 96
More...Cysteine 65 and cysteine 126
Cysteine 95 and cysteine 131
Cysteine 96 and cysteine 126
Cysteine 39 and cysteine 128
Cysteine 39 and cysteine 69
Cysteine 39 and cysteine 126
Cysteine 93 and cysteine 95
Cysteine 69 and cysteine 96
Cysteine 93 and cysteine 131
Cysteine 65 and cysteine 96
Cysteine 96 and cysteine 128
Cysteine 39 and cysteine 65
Cysteine 126 and cysteine 128
Cysteine 95 and cysteine 128
Cysteine 128 and cysteine 131
Cysteine 69 and cysteine 126
Cysteine 65 and cysteine 128
Cysteine 69 and cysteine 95
Cysteine 95 and cysteine 96
Cysteine 39 and cysteine 95
Cysteine 65 and cysteine 69
5cl1 A 1131 B 1131
A redox-regulated disulphide may form between two units of Norrin at cysteines 131 and 131 (1131 and 1131 respectively in this structure).
Details
Redox score ?
88
PDB code
5cl1
Structure name
complex structure of norrin with human frizzled 4
Structure deposition date
2015-07-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide A name
Norrin
Peptide B name
Norrin
Peptide A accession
Q00604
Peptide B accession
Q00604
Peptide A residue number
131
Peptide B residue number
131
Ligandability
5bpu E 93 F 93
A redox-regulated disulphide may form between two units of Norrin at cysteines 93 and 93.
Details
Redox score ?
72
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
Norrin
Peptide B name
Norrin
Peptide A accession
Q00604
Peptide B accession
Q00604
Peptide A residue number
93
Peptide B residue number
93
Ligandability
5bpu A 93 B 69
A redox-regulated disulphide may form between two units of Norrin at cysteines 93 and 69.
Details
Redox score ?
61
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Norrin
Peptide B name
Norrin
Peptide A accession
Q00604
Peptide B accession
Q00604
Peptide A residue number
93
Peptide B residue number
69
Ligandability
Cysteine 93 of Norrin
Cysteine 69 of Norrin
5bqb C 95 D 95
A redox-regulated disulphide may form between two units of Norrin at cysteines 95 and 95.
Details
Redox score ?
61
PDB code
5bqb
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form iii
Structure deposition date
2015-05-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide A name
Norrin
Peptide B name
Norrin
Peptide A accession
Q00604
Peptide B accession
Q00604
Peptide A residue number
95
Peptide B residue number
95
Ligandability
5bq8 A 93 B 128
A redox-regulated disulphide may form between two units of Norrin at cysteines 93 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5bq8
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form ii
Structure deposition date
2015-05-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide A name
Norrin
Peptide B name
Norrin
Peptide A accession
Q00604
Peptide B accession
Q00604
Peptide A residue number
93
Peptide B residue number
128
Ligandability
Cysteine 93 of Norrin
Cysteine 128 of Norrin
5bpu C 93 D 96
A redox-regulated disulphide may form between two units of Norrin at cysteines 93 and 96. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
Norrin
Peptide B name
Norrin
Peptide A accession
Q00604
Peptide B accession
Q00604
Peptide A residue number
93
Peptide B residue number
96
Ligandability
Cysteine 93 of Norrin
Cysteine 96 of Norrin
5bq8 C 93 D 39
A redox-regulated disulphide may form between two units of Norrin at cysteines 93 and 39. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
5bq8
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form ii
Structure deposition date
2015-05-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Norrin
Peptide B name
Norrin
Peptide A accession
Q00604
Peptide B accession
Q00604
Peptide A residue number
93
Peptide B residue number
39
Ligandability
Cysteine 93 of Norrin
Cysteine 39 of Norrin
5bqb C 55 C 110
A redox-regulated disulphide may form within Norrin between cysteines 55 and 110.
Details
Redox score ?
91
PDB code
5bqb
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form iii
Structure deposition date
2015-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
55
Residue number B
110
Peptide name
Norrin
Ligandability
Cysteine 55 of Norrin
Cysteine 110 of Norrin
5bq8 D 69 D 128
A redox-regulated disulphide may form within Norrin between cysteines 69 and 128.
Details
Redox score ?
85
PDB code
5bq8
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form ii
Structure deposition date
2015-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
69
Residue number B
128
Peptide name
Norrin
Ligandability
Cysteine 69 of Norrin
Cysteine 128 of Norrin
5bqe A 39 A 96
A redox-regulated disulphide may form within Norrin between cysteines 39 and 96.
Details
Redox score ?
83
PDB code
5bqe
Structure name
crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 -methylated form
Structure deposition date
2015-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
39
Residue number B
96
Peptide name
Norrin
Ligandability
Cysteine 39 of Norrin
Cysteine 96 of Norrin
5bqb B 65 B 126
A redox-regulated disulphide may form within Norrin between cysteines 65 and 126.
Details
Redox score ?
82
PDB code
5bqb
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form iii
Structure deposition date
2015-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
65
Residue number B
126
Peptide name
Norrin
Ligandability
Cysteine 65 of Norrin
Cysteine 126 of Norrin
5bpu E 95 E 131
A redox-regulated disulphide may form within Norrin between cysteines 95 and 131.
Details
Redox score ?
75
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
95
Residue number B
131
Peptide name
Norrin
Ligandability
Cysteine 95 of Norrin
Cysteine 131 of Norrin
5bpu A 96 A 126
A redox-regulated disulphide may form within Norrin between cysteines 96 and 126.
Details
Redox score ?
75
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
96
Residue number B
126
Peptide name
Norrin
Ligandability
Cysteine 96 of Norrin
Cysteine 126 of Norrin
5bqe B 39 B 128
A redox-regulated disulphide may form within Norrin between cysteines 39 and 128.
Details
Redox score ?
74
PDB code
5bqe
Structure name
crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 -methylated form
Structure deposition date
2015-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
39
Residue number B
128
Peptide name
Norrin
Ligandability
Cysteine 39 of Norrin
Cysteine 128 of Norrin
5bpu E 39 E 69
A redox-regulated disulphide may form within Norrin between cysteines 39 and 69.
Details
Redox score ?
72
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
39
Residue number B
69
Peptide name
Norrin
Ligandability
Cysteine 39 of Norrin
Cysteine 69 of Norrin
5bqb C 39 C 126
A redox-regulated disulphide may form within Norrin between cysteines 39 and 126.
Details
Redox score ?
71
PDB code
5bqb
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form iii
Structure deposition date
2015-05-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
39
Residue number B
126
Peptide name
Norrin
Ligandability
Cysteine 39 of Norrin
Cysteine 126 of Norrin
5bpu D 93 D 95
A redox-regulated disulphide may form within Norrin between cysteines 93 and 95.
Details
Redox score ?
67
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
93
Residue number B
95
Peptide name
Norrin
Ligandability
Cysteine 93 of Norrin
Cysteine 95 of Norrin
5bpu E 69 E 96
A redox-regulated disulphide may form within Norrin between cysteines 69 and 96.
Details
Redox score ?
66
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
69
Residue number B
96
Peptide name
Norrin
Ligandability
Cysteine 69 of Norrin
Cysteine 96 of Norrin
5bq8 D 93 D 131
A redox-regulated disulphide may form within Norrin between cysteines 93 and 131.
Details
Redox score ?
65
PDB code
5bq8
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form ii
Structure deposition date
2015-05-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
93
Residue number B
131
Peptide name
Norrin
Ligandability
Cysteine 93 of Norrin
Cysteine 131 of Norrin
5bq8 B 65 B 96
A redox-regulated disulphide may form within Norrin between cysteines 65 and 96.
Details
Redox score ?
64
PDB code
5bq8
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form ii
Structure deposition date
2015-05-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
65
Residue number B
96
Peptide name
Norrin
Ligandability
Cysteine 65 of Norrin
Cysteine 96 of Norrin
5bq8 B 96 B 128
A redox-regulated disulphide may form within Norrin between cysteines 96 and 128.
Details
Redox score ?
64
PDB code
5bq8
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form ii
Structure deposition date
2015-05-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
96
Residue number B
128
Peptide name
Norrin
Ligandability
Cysteine 96 of Norrin
Cysteine 128 of Norrin
5bqb B 39 B 65
A redox-regulated disulphide may form within Norrin between cysteines 39 and 65.
Details
Redox score ?
63
PDB code
5bqb
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form iii
Structure deposition date
2015-05-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
39
Residue number B
65
Peptide name
Norrin
Ligandability
Cysteine 39 of Norrin
Cysteine 65 of Norrin
5bpu F 126 F 128
A redox-regulated disulphide may form within Norrin between cysteines 126 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
126
Residue number B
128
Peptide name
Norrin
Ligandability
Cysteine 126 of Norrin
Cysteine 128 of Norrin
5bqe A 95 A 128
A redox-regulated disulphide may form within Norrin between cysteines 95 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5bqe
Structure name
crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 -methylated form
Structure deposition date
2015-05-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
95
Residue number B
128
Peptide name
Norrin
Ligandability
Cysteine 95 of Norrin
Cysteine 128 of Norrin
5bpu E 128 E 131
A redox-regulated disulphide may form within Norrin between cysteines 128 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
128
Residue number B
131
Peptide name
Norrin
Ligandability
Cysteine 128 of Norrin
Cysteine 131 of Norrin
5bqc A 69 A 126
A redox-regulated disulphide may form within Norrin between cysteines 69 and 126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
5bqc
Structure name
crystal structure of norrin in complex with the cysteine-rich domain of frizzled 4 and sucrose octasulfate
Structure deposition date
2015-05-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
69
Residue number B
126
Peptide name
Norrin
Ligandability
Cysteine 69 of Norrin
Cysteine 126 of Norrin
5bpu C 65 C 128
A redox-regulated disulphide may form within Norrin between cysteines 65 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
65
Residue number B
128
Peptide name
Norrin
Ligandability
Cysteine 65 of Norrin
Cysteine 128 of Norrin
5bpu F 69 F 95
A redox-regulated disulphide may form within Norrin between cysteines 69 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
69
Residue number B
95
Peptide name
Norrin
Ligandability
Cysteine 69 of Norrin
Cysteine 95 of Norrin
5bpu D 95 D 96
A redox-regulated disulphide may form within Norrin between cysteines 95 and 96. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
95
Residue number B
96
Peptide name
Norrin
Ligandability
Cysteine 95 of Norrin
Cysteine 96 of Norrin
5bpu E 39 E 95
A redox-regulated disulphide may form within Norrin between cysteines 39 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
39
Residue number B
95
Peptide name
Norrin
Ligandability
Cysteine 39 of Norrin
Cysteine 95 of Norrin
5bpu A 65 A 69
A redox-regulated disulphide may form within Norrin between cysteines 65 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5bpu
Structure name
crystal structure of norrin, a wnt signalling activator, crystal form i
Structure deposition date
2015-05-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00604
Residue number A
65
Residue number B
69
Peptide name
Norrin
Ligandability
Cysteine 65 of Norrin
Cysteine 69 of Norrin
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