a tool for identifying drug-targetable redox-active disulphides

Nuclear factor NF-kappa-B p100 subunit

Intramolecular

Cysteine 114 and cysteine 120

A redox-regulated disulphide may form within Nuclear factor NF-kappa-B p100 subunit between cysteines 114 and 120.

Details

Redox score ?

77

PDB code

Structure name

human nf-kappa-b p52 bound to dna

Structure deposition date

1998-01-23

Thiol separation (Å)

4

Half-sphere exposure sum ?

59

Minimum pK_a ?

7

% buried

58

Peptide accession

Residue number A

114

Residue number B

120

Peptide name

Nuclear factor NF-kappa-B p100 subunit

Ligandability

Cysteine 114 of Nuclear factor NF-kappa-B p100 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Nuclear factor NF-kappa-B p100 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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