ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Intramolecular
Cysteine 353 and cysteine 355
Cysteine 296 and cysteine 781
Cysteine 360 and cysteine 424
Cysteine 216 and cysteine 296
A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 between cysteines 353 and 355. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2fju
Structure name
activated rac1 bound to its effector phospholipase c beta 2
Structure deposition date
2006-01-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
95
Minimum pKa ?
11
% buried
100
Peptide accession
Q00722
Residue number A
353
Residue number B
355
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Ligandability

Cysteine 353 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 355 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 between cysteines 296 and 781 (296 and 777 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2fju
Structure name
activated rac1 bound to its effector phospholipase c beta 2
Structure deposition date
2006-01-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
100
Peptide accession
Q00722
Residue number A
296
Residue number B
781
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Ligandability

Cysteine 296 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 781 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 between cysteines 360 and 424. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2fju
Structure name
activated rac1 bound to its effector phospholipase c beta 2
Structure deposition date
2006-01-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
100
Peptide accession
Q00722
Residue number A
360
Residue number B
424
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Ligandability

Cysteine 360 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 424 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 between cysteines 216 and 296. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2fju
Structure name
activated rac1 bound to its effector phospholipase c beta 2
Structure deposition date
2006-01-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
100
Peptide accession
Q00722
Residue number A
216
Residue number B
296
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Ligandability

Cysteine 216 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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