ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Voltage-dependent N-type calcium channel subunit alpha-1B

Intermolecular
Cysteine 1322 and cysteine 46 of Omega-conotoxin MVIIA
Cysteine 1311 and cysteine 46 of Omega-conotoxin MVIIA
Intramolecular
Cysteine 1311 and cysteine 1322
Cysteine 1670 and cysteine 1679
Cysteine 253 and cysteine 277
Cysteine 268 and cysteine 283
Cysteine 277 and cysteine 283
Cysteine 268 and cysteine 277
Cysteine 253 and cysteine 268
Cysteine 253 and cysteine 283
Cysteine 1664 and cysteine 1679
A redox-regulated disulphide may form between cysteine 1322 of Voltage-dependent N-type calcium channel subunit alpha-1B and cysteine 46 of Omega-conotoxin MVIIA (1322 and 1 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7vfu
Structure name
human n-type voltage gated calcium channel cav2
Structure deposition date
2021-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Voltage-dependent N-type calcium channel subunit alpha-1B
Peptide B name
Omega-conotoxin MVIIA
Peptide A accession
Q00975
Peptide B accession
P05484
Peptide A residue number
1322
Peptide B residue number
46

Ligandability

Cysteine 1322 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of Omega-conotoxin MVIIA

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 1311 of Voltage-dependent N-type calcium channel subunit alpha-1B and cysteine 46 of Omega-conotoxin MVIIA (1311 and 1 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7mix
Structure name
human n-type voltage-gated calcium channel cav2
Structure deposition date
2021-04-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Voltage-dependent N-type calcium channel subunit alpha-1B
Peptide B name
Omega-conotoxin MVIIA
Peptide A accession
Q00975
Peptide B accession
P05484
Peptide A residue number
1311
Peptide B residue number
46

Ligandability

Cysteine 1311 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of Omega-conotoxin MVIIA

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent N-type calcium channel subunit alpha-1B between cysteines 1311 and 1322.

Details

Redox score ?
87
PDB code
7miy
Structure name
human n-type voltage-gated calcium channel cav2
Structure deposition date
2021-04-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00975
Residue number A
1311
Residue number B
1322
Peptide name
Voltage-dependent N-type calcium channel subunit alpha-1B

Ligandability

Cysteine 1311 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1322 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent N-type calcium channel subunit alpha-1B between cysteines 1670 and 1679.

Details

Redox score ?
86
PDB code
7vfs
Structure name
human n-type voltage gated calcium channel cav2
Structure deposition date
2021-09-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00975
Residue number A
1670
Residue number B
1679
Peptide name
Voltage-dependent N-type calcium channel subunit alpha-1B

Ligandability

Cysteine 1670 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1679 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent N-type calcium channel subunit alpha-1B between cysteines 253 and 277.

Details

Redox score ?
83
PDB code
7vfv
Structure name
human n-type voltage gated calcium channel cav2
Structure deposition date
2021-09-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00975
Residue number A
253
Residue number B
277
Peptide name
Voltage-dependent N-type calcium channel subunit alpha-1B

Ligandability

Cysteine 253 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent N-type calcium channel subunit alpha-1B between cysteines 268 and 283.

Details

Redox score ?
81
PDB code
7vfu
Structure name
human n-type voltage gated calcium channel cav2
Structure deposition date
2021-09-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00975
Residue number A
268
Residue number B
283
Peptide name
Voltage-dependent N-type calcium channel subunit alpha-1B

Ligandability

Cysteine 268 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent N-type calcium channel subunit alpha-1B between cysteines 277 and 283.

Details

Redox score ?
80
PDB code
7miy
Structure name
human n-type voltage-gated calcium channel cav2
Structure deposition date
2021-04-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00975
Residue number A
277
Residue number B
283
Peptide name
Voltage-dependent N-type calcium channel subunit alpha-1B

Ligandability

Cysteine 277 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent N-type calcium channel subunit alpha-1B between cysteines 268 and 277.

Details

Redox score ?
71
PDB code
7miy
Structure name
human n-type voltage-gated calcium channel cav2
Structure deposition date
2021-04-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00975
Residue number A
268
Residue number B
277
Peptide name
Voltage-dependent N-type calcium channel subunit alpha-1B

Ligandability

Cysteine 268 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent N-type calcium channel subunit alpha-1B between cysteines 253 and 268.

Details

Redox score ?
66
PDB code
7vfs
Structure name
human n-type voltage gated calcium channel cav2
Structure deposition date
2021-09-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00975
Residue number A
253
Residue number B
268
Peptide name
Voltage-dependent N-type calcium channel subunit alpha-1B

Ligandability

Cysteine 253 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 268 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent N-type calcium channel subunit alpha-1B between cysteines 253 and 283.

Details

Redox score ?
63
PDB code
7vfw
Structure name
human n-type voltage gated calcium channel cav2
Structure deposition date
2021-09-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q00975
Residue number A
253
Residue number B
283
Peptide name
Voltage-dependent N-type calcium channel subunit alpha-1B

Ligandability

Cysteine 253 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent N-type calcium channel subunit alpha-1B between cysteines 1664 and 1679. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7mix
Structure name
human n-type voltage-gated calcium channel cav2
Structure deposition date
2021-04-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
nan
Peptide accession
Q00975
Residue number A
1664
Residue number B
1679
Peptide name
Voltage-dependent N-type calcium channel subunit alpha-1B

Ligandability

Cysteine 1664 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1679 of Voltage-dependent N-type calcium channel subunit alpha-1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: