a tool for identifying drug-targetable redox-active disulphides

Transcription factor E2F1

Intramolecular

Cysteine 248 and cysteine 298

A redox-regulated disulphide may form within Transcription factor E2F1 between cysteines 248 and 298.

Details

Redox score ?

73

PDB code

Structure name

structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer

Structure deposition date

2005-09-10

Thiol separation (Å)

4

Half-sphere exposure sum ?

62

Minimum pK_a ?

10

% buried

43

Peptide accession

Residue number A

248

Residue number B

298

Peptide name

Transcription factor E2F1

Ligandability

Cysteine 248 of Transcription factor E2F1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 298 of Transcription factor E2F1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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