Insulinoma-associated protein 1
Intramolecular
Cysteine 471 and cysteine 474
Cysteine 443 and cysteine 446
Cysteine 474 and cysteine 491
Cysteine 471 and cysteine 491
2lv2 A 59 A 62
A redox-regulated disulphide may form within Insulinoma-associated protein 1 between cysteines 471 and 474 (59 and 62 respectively in this structure).
Details
Redox score ?
83
PDB code
2lv2
Structure name
solution nmr structure of c2h2-type zinc-fingers 4 and 5 from human insulinoma-associated protein 1 (fragment 424-497), northeast structural genomics consortium target hr7614b
Structure deposition date
2012-06-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
8
% buried
0
Peptide accession
Q01101
Residue number A
471
Residue number B
474
Peptide name
Insulinoma-associated protein 1
Ligandability
Cysteine 471 of Insulinoma-associated protein 1
Cysteine 474 of Insulinoma-associated protein 1
2lv2 A 31 A 34
A redox-regulated disulphide may form within Insulinoma-associated protein 1 between cysteines 443 and 446 (31 and 34 respectively in this structure).
Details
Redox score ?
82
PDB code
2lv2
Structure name
solution nmr structure of c2h2-type zinc-fingers 4 and 5 from human insulinoma-associated protein 1 (fragment 424-497), northeast structural genomics consortium target hr7614b
Structure deposition date
2012-06-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
8
% buried
2
Peptide accession
Q01101
Residue number A
443
Residue number B
446
Peptide name
Insulinoma-associated protein 1
Ligandability
Cysteine 443 of Insulinoma-associated protein 1
Cysteine 446 of Insulinoma-associated protein 1
2lv2 A 62 A 79
A redox-regulated disulphide may form within Insulinoma-associated protein 1 between cysteines 474 and 491 (62 and 79 respectively in this structure).
Details
Redox score ?
62
PDB code
2lv2
Structure name
solution nmr structure of c2h2-type zinc-fingers 4 and 5 from human insulinoma-associated protein 1 (fragment 424-497), northeast structural genomics consortium target hr7614b
Structure deposition date
2012-06-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
31
Minimum pKa ?
8
% buried
0
Peptide accession
Q01101
Residue number A
474
Residue number B
491
Peptide name
Insulinoma-associated protein 1
Ligandability
Cysteine 474 of Insulinoma-associated protein 1
Cysteine 491 of Insulinoma-associated protein 1
2lv2 A 59 A 79
A redox-regulated disulphide may form within Insulinoma-associated protein 1 between cysteines 471 and 491 (59 and 79 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
2lv2
Structure name
solution nmr structure of c2h2-type zinc-fingers 4 and 5 from human insulinoma-associated protein 1 (fragment 424-497), northeast structural genomics consortium target hr7614b
Structure deposition date
2012-06-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
0
Peptide accession
Q01101
Residue number A
471
Residue number B
491
Peptide name
Insulinoma-associated protein 1
Ligandability
Cysteine 471 of Insulinoma-associated protein 1
Cysteine 491 of Insulinoma-associated protein 1
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