ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-9 receptor

Intramolecular
Cysteine 56 and cysteine 66
Cysteine 95 and cysteine 102
Cysteine 66 and cysteine 102
Cysteine 66 and cysteine 95
Cysteine 56 and cysteine 102
Cysteine 56 and cysteine 95
A redox-regulated disulphide may form within Interleukin-9 receptor between cysteines 56 and 66.

Details

Redox score ?
84
PDB code
7ox5
Structure name
hil-9:hil-9ra complex
Structure deposition date
2021-06-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01113
Residue number A
56
Residue number B
66
Peptide name
Interleukin-9 receptor

Ligandability

Cysteine 56 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-9 receptor between cysteines 95 and 102.

Details

Redox score ?
83
PDB code
7ox5
Structure name
hil-9:hil-9ra complex
Structure deposition date
2021-06-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01113
Residue number A
95
Residue number B
102
Peptide name
Interleukin-9 receptor

Ligandability

Cysteine 95 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-9 receptor between cysteines 66 and 102.

Details

Redox score ?
70
PDB code
7ox5
Structure name
hil-9:hil-9ra complex
Structure deposition date
2021-06-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01113
Residue number A
66
Residue number B
102
Peptide name
Interleukin-9 receptor

Ligandability

Cysteine 66 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-9 receptor between cysteines 66 and 95.

Details

Redox score ?
66
PDB code
7ox5
Structure name
hil-9:hil-9ra complex
Structure deposition date
2021-06-22
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01113
Residue number A
66
Residue number B
95
Peptide name
Interleukin-9 receptor

Ligandability

Cysteine 66 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-9 receptor between cysteines 56 and 102.

Details

Redox score ?
60
PDB code
7ox5
Structure name
hil-9:hil-9ra complex
Structure deposition date
2021-06-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01113
Residue number A
56
Residue number B
102
Peptide name
Interleukin-9 receptor

Ligandability

Cysteine 56 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-9 receptor between cysteines 56 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
7ox5
Structure name
hil-9:hil-9ra complex
Structure deposition date
2021-06-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01113
Residue number A
56
Residue number B
95
Peptide name
Interleukin-9 receptor

Ligandability

Cysteine 56 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Interleukin-9 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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