ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sodium channel protein type 7 subunit alpha

Intermolecular
Cysteine 927 and cysteine 180 of Sodium channel subunit beta-3
Intramolecular
Cysteine 696 and cysteine 705
Cysteine 1087 and cysteine 1107
Cysteine 1451 and cysteine 1466
Cysteine 267 and cysteine 316
Cysteine 658 and cysteine 664
Cysteine 307 and cysteine 316
Cysteine 316 and cysteine 322
Cysteine 267 and cysteine 307
Cysteine 267 and cysteine 322
More...
Cysteine 307 and cysteine 322
Cysteine 927 and cysteine 928
A redox-regulated disulphide may form between cysteine 927 of Sodium channel protein type 7 subunit alpha and cysteine 180 of Sodium channel subunit beta-3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
18
Peptide A name
Sodium channel protein type 7 subunit alpha
Peptide B name
Sodium channel subunit beta-3
Peptide A accession
Q01118
Peptide B accession
Q9NY72
Peptide A residue number
927
Peptide B residue number
180

Ligandability

Cysteine 927 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Sodium channel subunit beta-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 7 subunit alpha between cysteines 696 and 705.

Details

Redox score ?
86
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01118
Residue number A
696
Residue number B
705
Peptide name
Sodium channel protein type 7 subunit alpha

Ligandability

Cysteine 696 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 705 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 7 subunit alpha between cysteines 1087 and 1107.

Details

Redox score ?
85
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01118
Residue number A
1087
Residue number B
1107
Peptide name
Sodium channel protein type 7 subunit alpha

Ligandability

Cysteine 1087 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1107 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 7 subunit alpha between cysteines 1451 and 1466.

Details

Redox score ?
85
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
2
Peptide accession
Q01118
Residue number A
1451
Residue number B
1466
Peptide name
Sodium channel protein type 7 subunit alpha

Ligandability

Cysteine 1451 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1466 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 7 subunit alpha between cysteines 267 and 316.

Details

Redox score ?
84
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
3
% buried
70
Peptide accession
Q01118
Residue number A
267
Residue number B
316
Peptide name
Sodium channel protein type 7 subunit alpha

Ligandability

Cysteine 267 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 7 subunit alpha between cysteines 658 and 664.

Details

Redox score ?
82
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
0
Peptide accession
Q01118
Residue number A
658
Residue number B
664
Peptide name
Sodium channel protein type 7 subunit alpha

Ligandability

Cysteine 658 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 664 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 7 subunit alpha between cysteines 307 and 316.

Details

Redox score ?
78
PDB code
7tj9
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in gdn
Structure deposition date
2022-01-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
79
Minimum pKa ?
7
% buried
nan
Peptide accession
Q01118
Residue number A
307
Residue number B
316
Peptide name
Sodium channel protein type 7 subunit alpha

Ligandability

Cysteine 307 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 7 subunit alpha between cysteines 316 and 322.

Details

Redox score ?
75
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
3
% buried
51
Peptide accession
Q01118
Residue number A
316
Residue number B
322
Peptide name
Sodium channel protein type 7 subunit alpha

Ligandability

Cysteine 316 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 7 subunit alpha between cysteines 267 and 307.

Details

Redox score ?
62
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
76
Peptide accession
Q01118
Residue number A
267
Residue number B
307
Peptide name
Sodium channel protein type 7 subunit alpha

Ligandability

Cysteine 267 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 7 subunit alpha between cysteines 267 and 322. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
64
Peptide accession
Q01118
Residue number A
267
Residue number B
322
Peptide name
Sodium channel protein type 7 subunit alpha

Ligandability

Cysteine 267 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 7 subunit alpha between cysteines 307 and 322. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7tj9
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in gdn
Structure deposition date
2022-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
15
% buried
nan
Peptide accession
Q01118
Residue number A
307
Residue number B
322
Peptide name
Sodium channel protein type 7 subunit alpha

Ligandability

Cysteine 307 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 7 subunit alpha between cysteines 927 and 928. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7tj8
Structure name
cryo-em structure of the human nax channel in complex with beta3 solved in nanodiscs
Structure deposition date
2022-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
15
Peptide accession
Q01118
Residue number A
927
Residue number B
928
Peptide name
Sodium channel protein type 7 subunit alpha

Ligandability

Cysteine 927 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 928 of Sodium channel protein type 7 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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