ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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AMP deaminase 2

Intramolecular
Cysteine 792 and cysteine 795
Cysteine 263 and cysteine 848
A redox-regulated disulphide may form within AMP deaminase 2 between cysteines 792 and 795. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
8hu6
Structure name
amp deaminase 2 in complex with amp
Structure deposition date
2022-12-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
13
% buried
100
Peptide accession
Q01433
Residue number A
792
Residue number B
795
Peptide name
AMP deaminase 2

Ligandability

Cysteine 792 of AMP deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 795 of AMP deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AMP deaminase 2 between cysteines 263 and 848. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
8hu6
Structure name
amp deaminase 2 in complex with amp
Structure deposition date
2022-12-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
73
Peptide accession
Q01433
Residue number A
263
Residue number B
848
Peptide name
AMP deaminase 2

Ligandability

Cysteine 263 of AMP deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 848 of AMP deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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