ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Adenylyl cyclase-associated protein 1

Intermolecular
Cysteine 92 and cysteine 92
Intramolecular
Cysteine 355 and cysteine 374
A redox-regulated disulphide may form between two units of Adenylyl cyclase-associated protein 1 at cysteines 92 and 92.

Details

Redox score ?
87
PDB code
6rsq
Structure name
helical folded domain of mouse cap1
Structure deposition date
2019-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide A name
Adenylyl cyclase-associated protein 1
Peptide B name
Adenylyl cyclase-associated protein 1
Peptide A accession
P40124
Peptide B accession
P40124
Peptide A residue number
92
Peptide B residue number
92

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adenylyl cyclase-associated protein 1 between cysteines 355 and 374.

Details

Redox score ?
72
PDB code
6fm2
Structure name
carp domain of mouse cyclase-associated protein 1 (cap1) bound to adp- actin
Structure deposition date
2018-01-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
7
% buried
84
Peptide accession
P40124
Residue number A
355
Residue number B
374
Peptide name
Adenylyl cyclase-associated protein 1

Ligandability

Cysteine 355 of Adenylyl cyclase-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 374 of Adenylyl cyclase-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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