ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Myelin transcription factor 1

Intramolecular
Cysteine 807 and cysteine 870
Cysteine 846 and cysteine 807
Cysteine 802 and cysteine 826
Cysteine 802 and cysteine 807
Cysteine 807 and cysteine 826
Cysteine 846 and cysteine 870
A redox-regulated disulphide may form within Myelin transcription factor 1 between cysteines 807 and 870 (851 and 870 respectively in this structure).

Details

Redox score ?
86
PDB code
2mf8
Structure name
haddock model of myt1 f4f5 - dna complex
Structure deposition date
2013-10-08
Thiol separation (Å)
3
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
6
Peptide accession
Q8CFC2
Residue number A
807
Residue number B
870
Peptide name
Myelin transcription factor 1

Ligandability

Cysteine 807 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 870 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myelin transcription factor 1 between cysteines 846 and 807 (12 and 17 respectively in this structure).

Details

Redox score ?
86
PDB code
2jyd
Structure name
structure of the fifth zinc finger of myelin transcription factor 1
Structure deposition date
2007-12-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
1
Peptide accession
Q8CFC2
Residue number A
846
Residue number B
807
Peptide name
Myelin transcription factor 1

Ligandability

Cysteine 846 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 807 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myelin transcription factor 1 between cysteines 802 and 826.

Details

Redox score ?
80
PDB code
2mf8
Structure name
haddock model of myt1 f4f5 - dna complex
Structure deposition date
2013-10-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
34
Peptide accession
Q8CFC2
Residue number A
802
Residue number B
826
Peptide name
Myelin transcription factor 1

Ligandability

Cysteine 802 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 826 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myelin transcription factor 1 between cysteines 802 and 807.

Details

Redox score ?
79
PDB code
2mf8
Structure name
haddock model of myt1 f4f5 - dna complex
Structure deposition date
2013-10-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
10
% buried
nan
Peptide accession
Q8CFC2
Residue number A
802
Residue number B
807
Peptide name
Myelin transcription factor 1

Ligandability

Cysteine 802 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 807 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myelin transcription factor 1 between cysteines 807 and 826.

Details

Redox score ?
79
PDB code
2mf8
Structure name
haddock model of myt1 f4f5 - dna complex
Structure deposition date
2013-10-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
nan
Peptide accession
Q8CFC2
Residue number A
807
Residue number B
826
Peptide name
Myelin transcription factor 1

Ligandability

Cysteine 807 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 826 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myelin transcription factor 1 between cysteines 846 and 870 (12 and 36 respectively in this structure).

Details

Redox score ?
73
PDB code
2jx1
Structure name
structure of the fifth zinc finger of myelin transcription factor 1 in complex with rare dna
Structure deposition date
2007-11-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
11
% buried
42
Peptide accession
Q8CFC2
Residue number A
846
Residue number B
870
Peptide name
Myelin transcription factor 1

Ligandability

Cysteine 846 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 870 of Myelin transcription factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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