ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-1 receptor-like 1

Intramolecular
Cysteine 111 and cysteine 151
Cysteine 36 and cysteine 87
Cysteine 235 and cysteine 303
Cysteine 133 and cysteine 181
Cysteine 238 and cysteine 282
A redox-regulated disulphide may form within Interleukin-1 receptor-like 1 between cysteines 111 and 151.

Details

Redox score ?
86
PDB code
4kc3
Structure name
cytokine/receptor binary complex
Structure deposition date
2013-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
34
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01638
Residue number A
111
Residue number B
151
Peptide name
Interleukin-1 receptor-like 1

Ligandability

Cysteine 111 of Interleukin-1 receptor-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Interleukin-1 receptor-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor-like 1 between cysteines 36 and 87.

Details

Redox score ?
84
PDB code
4kc3
Structure name
cytokine/receptor binary complex
Structure deposition date
2013-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01638
Residue number A
36
Residue number B
87
Peptide name
Interleukin-1 receptor-like 1

Ligandability

Cysteine 36 of Interleukin-1 receptor-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of Interleukin-1 receptor-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor-like 1 between cysteines 235 and 303.

Details

Redox score ?
81
PDB code
4kc3
Structure name
cytokine/receptor binary complex
Structure deposition date
2013-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01638
Residue number A
235
Residue number B
303
Peptide name
Interleukin-1 receptor-like 1

Ligandability

Cysteine 235 of Interleukin-1 receptor-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 303 of Interleukin-1 receptor-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor-like 1 between cysteines 133 and 181.

Details

Redox score ?
80
PDB code
4kc3
Structure name
cytokine/receptor binary complex
Structure deposition date
2013-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01638
Residue number A
133
Residue number B
181
Peptide name
Interleukin-1 receptor-like 1

Ligandability

Cysteine 133 of Interleukin-1 receptor-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of Interleukin-1 receptor-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor-like 1 between cysteines 238 and 282.

Details

Redox score ?
79
PDB code
4kc3
Structure name
cytokine/receptor binary complex
Structure deposition date
2013-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01638
Residue number A
238
Residue number B
282
Peptide name
Interleukin-1 receptor-like 1

Ligandability

Cysteine 238 of Interleukin-1 receptor-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of Interleukin-1 receptor-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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