ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Large neutral amino acids transporter small subunit 1

Intermolecular
Cysteine 164 and cysteine 210 of 4F2 cell-surface antigen heavy chain
Intramolecular
Cysteine 102 and cysteine 443
Cysteine 187 and cysteine 381
Cysteine 178 and cysteine 335
Cysteine 176 and cysteine 381
Cysteine 176 and cysteine 178
A redox-regulated disulphide may form between cysteine 164 of Large neutral amino acids transporter small subunit 1 and cysteine 210 of 4F2 cell-surface antigen heavy chain.

Details

Redox score ?
87
PDB code
6jmq
Structure name
lat1-cd98hc complex bound to mem-108 fab
Structure deposition date
2019-03-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide A name
Large neutral amino acids transporter small subunit 1
Peptide B name
4F2 cell-surface antigen heavy chain
Peptide A accession
Q01650
Peptide B accession
P08195
Peptide A residue number
164
Peptide B residue number
210

Ligandability

Cysteine 164 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of 4F2 cell-surface antigen heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Large neutral amino acids transporter small subunit 1 between cysteines 102 and 443. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6jmq
Structure name
lat1-cd98hc complex bound to mem-108 fab
Structure deposition date
2019-03-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
68
Peptide accession
Q01650
Residue number A
102
Residue number B
443
Peptide name
Large neutral amino acids transporter small subunit 1

Ligandability

Cysteine 102 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 443 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Large neutral amino acids transporter small subunit 1 between cysteines 187 and 381. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7dsq
Structure name
overall structure of the lat1-4f2hc bound with 3,5-diiodo-l-tyrosine
Structure deposition date
2020-12-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
96
Peptide accession
Q01650
Residue number A
187
Residue number B
381
Peptide name
Large neutral amino acids transporter small subunit 1

Ligandability

Cysteine 187 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 381 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Large neutral amino acids transporter small subunit 1 between cysteines 178 and 335. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6irt
Structure name
human lat1-4f2hc complex bound with bch
Structure deposition date
2018-11-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
98
Peptide accession
Q01650
Residue number A
178
Residue number B
335
Peptide name
Large neutral amino acids transporter small subunit 1

Ligandability

Cysteine 178 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Large neutral amino acids transporter small subunit 1 between cysteines 176 and 381. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7dsl
Structure name
overall structure of the lat1-4f2hc bound with jx-078
Structure deposition date
2020-12-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
77
Peptide accession
Q01650
Residue number A
176
Residue number B
381
Peptide name
Large neutral amino acids transporter small subunit 1

Ligandability

Cysteine 176 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 381 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Large neutral amino acids transporter small subunit 1 between cysteines 176 and 178. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6irs
Structure name
human lat1-4f2hc complex incubated with jph203
Structure deposition date
2018-11-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
79
Peptide accession
Q01650
Residue number A
176
Residue number B
178
Peptide name
Large neutral amino acids transporter small subunit 1

Ligandability

Cysteine 176 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Large neutral amino acids transporter small subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: