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Voltage-dependent L-type calcium channel subunit alpha-1D

Intramolecular
Cysteine 1044 and cysteine 1055
Cysteine 1421 and cysteine 1435
Cysteine 301 and cysteine 326
Cysteine 317 and cysteine 333
Cysteine 326 and cysteine 333
Cysteine 317 and cysteine 326
Cysteine 301 and cysteine 317
Cysteine 301 and cysteine 333
Cysteine 1522 and cysteine 1528
Cysteine 592 and cysteine 596
More...
Cysteine 1402 and cysteine 1415
Cysteine 1402 and cysteine 1451
Cysteine 1415 and cysteine 1435
Cysteine 620 and cysteine 1031
A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 1044 and 1055.

Details

Redox score ?
87
PDB code
8e5b
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01668
Residue number A
1044
Residue number B
1055
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 1044 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1055 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 1421 and 1435.

Details

Redox score ?
86
PDB code
8e5a
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01668
Residue number A
1421
Residue number B
1435
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 1421 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1435 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 301 and 326.

Details

Redox score ?
85
PDB code
8e59
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01668
Residue number A
301
Residue number B
326
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 301 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 326 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 317 and 333.

Details

Redox score ?
81
PDB code
8e5b
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01668
Residue number A
317
Residue number B
333
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 317 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 333 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 326 and 333.

Details

Redox score ?
79
PDB code
8e59
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01668
Residue number A
326
Residue number B
333
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 326 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 333 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 317 and 326.

Details

Redox score ?
69
PDB code
7uhf
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-03-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01668
Residue number A
317
Residue number B
326
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 317 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 326 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 301 and 317.

Details

Redox score ?
66
PDB code
8e59
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01668
Residue number A
301
Residue number B
317
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 301 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 301 and 333.

Details

Redox score ?
60
PDB code
7uhg
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-03-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01668
Residue number A
301
Residue number B
333
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 301 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 333 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 1522 and 1528. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
8e59
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
33
Minimum pKa ?
9
% buried
0
Peptide accession
Q01668
Residue number A
1522
Residue number B
1528
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 1522 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1528 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 592 and 596. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7uhg
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-03-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
6
Peptide accession
Q01668
Residue number A
592
Residue number B
596
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 592 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 596 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 1402 and 1415. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7uhf
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-03-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
100
Peptide accession
Q01668
Residue number A
1402
Residue number B
1415
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 1402 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1415 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 1402 and 1451. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
8e5a
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
90
Peptide accession
Q01668
Residue number A
1402
Residue number B
1451
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 1402 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1451 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 1415 and 1435. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7uhg
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-03-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
nan
Peptide accession
Q01668
Residue number A
1415
Residue number B
1435
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 1415 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1435 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent L-type calcium channel subunit alpha-1D between cysteines 620 and 1031. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
8e5b
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
69
Peptide accession
Q01668
Residue number A
620
Residue number B
1031
Peptide name
Voltage-dependent L-type calcium channel subunit alpha-1D

Ligandability

Cysteine 620 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1031 of Voltage-dependent L-type calcium channel subunit alpha-1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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