ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Intramolecular
Cysteine 358 and cysteine 360
Cysteine 824 and cysteine 834
A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 between cysteines 358 and 360. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7sq2
Structure name
reprocessed and refined structure of phospholipase c-beta and gq signaling complex
Structure deposition date
2021-11-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
91
Minimum pKa ?
10
% buried
100
Peptide accession
Q01970
Residue number A
358
Residue number B
360
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Ligandability

Cysteine 358 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 360 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 between cysteines 824 and 834. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4gnk
Structure name
crystal structure of galphaq in complex with full-length human plcbeta3
Structure deposition date
2012-08-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
96
Peptide accession
Q01970
Residue number A
824
Residue number B
834
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Ligandability

Cysteine 824 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 834 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: