Inactive tyrosine-protein kinase transmembrane receptor ROR1
Intramolecular
Cysteine 362 and cysteine 386
Cysteine 313 and cysteine 391
Cysteine 334 and cysteine 374
Cysteine 713 and cysteine 717
Cysteine 334 and cysteine 362
Cysteine 334 and cysteine 386
Cysteine 374 and cysteine 386
Cysteine 362 and cysteine 374
7tng A 362 A 386
A redox-regulated disulphide may form within Inactive tyrosine-protein kinase transmembrane receptor ROR1 between cysteines 362 and 386.
Details
Redox score ?
83
PDB code
7tng
Structure name
kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ror1)
Structure deposition date
2022-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01973
Residue number A
362
Residue number B
386
Peptide name
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Ligandability
Cysteine 362 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
Cysteine 386 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
6ba5 O 313 O 391
A redox-regulated disulphide may form within Inactive tyrosine-protein kinase transmembrane receptor ROR1 between cysteines 313 and 391.
Details
Redox score ?
83
PDB code
6ba5
Structure name
potent and selective antitumor activity of a t-cell engaging bispecific antibody targeting a membrane-proximal epitope of ror1
Structure deposition date
2017-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
0
Peptide accession
Q01973
Residue number A
313
Residue number B
391
Peptide name
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Ligandability
Cysteine 313 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
Cysteine 391 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
7tng A 334 A 374
A redox-regulated disulphide may form within Inactive tyrosine-protein kinase transmembrane receptor ROR1 between cysteines 334 and 374.
Details
Redox score ?
81
PDB code
7tng
Structure name
kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ror1)
Structure deposition date
2022-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01973
Residue number A
334
Residue number B
374
Peptide name
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Ligandability
Cysteine 334 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
Cysteine 374 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
6tu9 A 713 A 717
A redox-regulated disulphide may form within Inactive tyrosine-protein kinase transmembrane receptor ROR1 between cysteines 713 and 717.
Details
Redox score ?
77
PDB code
6tu9
Structure name
the ror1 pseudokinase domain bound to ponatinib
Structure deposition date
2020-01-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
20
Peptide accession
Q01973
Residue number A
713
Residue number B
717
Peptide name
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Ligandability
Cysteine 713 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
Cysteine 717 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
6ban M 334 M 362
A redox-regulated disulphide may form within Inactive tyrosine-protein kinase transmembrane receptor ROR1 between cysteines 334 and 362.
Details
Redox score ?
71
PDB code
6ban
Structure name
potent and selective antitumor activity of a t-cell engaging bispecific antibody targeting a membrane-proximal epitope of ror1
Structure deposition date
2017-10-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01973
Residue number A
334
Residue number B
362
Peptide name
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Ligandability
Cysteine 334 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
Cysteine 362 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
6ban M 334 M 386
A redox-regulated disulphide may form within Inactive tyrosine-protein kinase transmembrane receptor ROR1 between cysteines 334 and 386.
Details
Redox score ?
70
PDB code
6ban
Structure name
potent and selective antitumor activity of a t-cell engaging bispecific antibody targeting a membrane-proximal epitope of ror1
Structure deposition date
2017-10-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01973
Residue number A
334
Residue number B
386
Peptide name
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Ligandability
Cysteine 334 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
Cysteine 386 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
6ba5 N 374 N 386
A redox-regulated disulphide may form within Inactive tyrosine-protein kinase transmembrane receptor ROR1 between cysteines 374 and 386.
Details
Redox score ?
70
PDB code
6ba5
Structure name
potent and selective antitumor activity of a t-cell engaging bispecific antibody targeting a membrane-proximal epitope of ror1
Structure deposition date
2017-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01973
Residue number A
374
Residue number B
386
Peptide name
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Ligandability
Cysteine 374 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
Cysteine 386 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
6ba5 O 362 O 374
A redox-regulated disulphide may form within Inactive tyrosine-protein kinase transmembrane receptor ROR1 between cysteines 362 and 374.
Details
Redox score ?
65
PDB code
6ba5
Structure name
potent and selective antitumor activity of a t-cell engaging bispecific antibody targeting a membrane-proximal epitope of ror1
Structure deposition date
2017-10-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01973
Residue number A
362
Residue number B
374
Peptide name
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Ligandability
Cysteine 362 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
Cysteine 374 of Inactive tyrosine-protein kinase transmembrane receptor ROR1
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