Tyrosine-protein kinase transmembrane receptor ROR2
Intramolecular
Cysteine 316 and cysteine 394
Cysteine 365 and cysteine 389
Cysteine 337 and cysteine 377
Cysteine 713 and cysteine 717
Cysteine 337 and cysteine 389
Cysteine 337 and cysteine 365
Cysteine 377 and cysteine 389
Cysteine 365 and cysteine 377
6osn A 316 A 394
A redox-regulated disulphide may form within Tyrosine-protein kinase transmembrane receptor ROR2 between cysteines 316 and 394.
Details
Redox score ?
87
PDB code
6osn
Structure name
potent and selective antitumor antibody targeting a membrane-proximal epitope of ror2
Structure deposition date
2019-05-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01974
Residue number A
316
Residue number B
394
Peptide name
Tyrosine-protein kinase transmembrane receptor ROR2
Ligandability
Cysteine 316 of Tyrosine-protein kinase transmembrane receptor ROR2
Cysteine 394 of Tyrosine-protein kinase transmembrane receptor ROR2
6osv K 365 K 389
A redox-regulated disulphide may form within Tyrosine-protein kinase transmembrane receptor ROR2 between cysteines 365 and 389.
Details
Redox score ?
82
PDB code
6osv
Structure name
potent and selective antitumor antibody targeting a membrane-proximal epitope of ror2
Structure deposition date
2019-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01974
Residue number A
365
Residue number B
389
Peptide name
Tyrosine-protein kinase transmembrane receptor ROR2
Ligandability
Cysteine 365 of Tyrosine-protein kinase transmembrane receptor ROR2
Cysteine 389 of Tyrosine-protein kinase transmembrane receptor ROR2
6osv K 337 K 377
A redox-regulated disulphide may form within Tyrosine-protein kinase transmembrane receptor ROR2 between cysteines 337 and 377.
Details
Redox score ?
81
PDB code
6osv
Structure name
potent and selective antitumor antibody targeting a membrane-proximal epitope of ror2
Structure deposition date
2019-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01974
Residue number A
337
Residue number B
377
Peptide name
Tyrosine-protein kinase transmembrane receptor ROR2
Ligandability
Cysteine 337 of Tyrosine-protein kinase transmembrane receptor ROR2
Cysteine 377 of Tyrosine-protein kinase transmembrane receptor ROR2
4gt4 A 713 A 717
A redox-regulated disulphide may form within Tyrosine-protein kinase transmembrane receptor ROR2 between cysteines 713 and 717.
Details
Redox score ?
74
PDB code
4gt4
Structure name
structure of unliganded, inactive ror2 kinase domain
Structure deposition date
2012-08-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
49
Minimum pKa ?
10
% buried
29
Peptide accession
Q01974
Residue number A
713
Residue number B
717
Peptide name
Tyrosine-protein kinase transmembrane receptor ROR2
Ligandability
Cysteine 713 of Tyrosine-protein kinase transmembrane receptor ROR2
Cysteine 717 of Tyrosine-protein kinase transmembrane receptor ROR2
6osh K 337 K 389
A redox-regulated disulphide may form within Tyrosine-protein kinase transmembrane receptor ROR2 between cysteines 337 and 389.
Details
Redox score ?
72
PDB code
6osh
Structure name
potent and selective antitumor antibody targeting a membrane-proximal epitope of ror2
Structure deposition date
2019-05-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01974
Residue number A
337
Residue number B
389
Peptide name
Tyrosine-protein kinase transmembrane receptor ROR2
Ligandability
Cysteine 337 of Tyrosine-protein kinase transmembrane receptor ROR2
Cysteine 389 of Tyrosine-protein kinase transmembrane receptor ROR2
6osv K 337 K 365
A redox-regulated disulphide may form within Tyrosine-protein kinase transmembrane receptor ROR2 between cysteines 337 and 365.
Details
Redox score ?
72
PDB code
6osv
Structure name
potent and selective antitumor antibody targeting a membrane-proximal epitope of ror2
Structure deposition date
2019-05-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01974
Residue number A
337
Residue number B
365
Peptide name
Tyrosine-protein kinase transmembrane receptor ROR2
Ligandability
Cysteine 337 of Tyrosine-protein kinase transmembrane receptor ROR2
Cysteine 365 of Tyrosine-protein kinase transmembrane receptor ROR2
6osn A 377 A 389
A redox-regulated disulphide may form within Tyrosine-protein kinase transmembrane receptor ROR2 between cysteines 377 and 389.
Details
Redox score ?
70
PDB code
6osn
Structure name
potent and selective antitumor antibody targeting a membrane-proximal epitope of ror2
Structure deposition date
2019-05-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01974
Residue number A
377
Residue number B
389
Peptide name
Tyrosine-protein kinase transmembrane receptor ROR2
Ligandability
Cysteine 377 of Tyrosine-protein kinase transmembrane receptor ROR2
Cysteine 389 of Tyrosine-protein kinase transmembrane receptor ROR2
6osn A 365 A 377
A redox-regulated disulphide may form within Tyrosine-protein kinase transmembrane receptor ROR2 between cysteines 365 and 377.
Details
Redox score ?
66
PDB code
6osn
Structure name
potent and selective antitumor antibody targeting a membrane-proximal epitope of ror2
Structure deposition date
2019-05-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q01974
Residue number A
365
Residue number B
377
Peptide name
Tyrosine-protein kinase transmembrane receptor ROR2
Ligandability
Cysteine 365 of Tyrosine-protein kinase transmembrane receptor ROR2
Cysteine 377 of Tyrosine-protein kinase transmembrane receptor ROR2
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