ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Contactin-2

Intramolecular
Cysteine 261 and cysteine 306
Cysteine 61 and cysteine 111
Cysteine 155 and cysteine 207
Cysteine 348 and cysteine 395
A redox-regulated disulphide may form within Contactin-2 between cysteines 261 and 306 (231 and 276 respectively in this structure).

Details

Redox score ?
82
PDB code
2om5
Structure name
n-terminal fragment of human tax1
Structure deposition date
2007-01-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q02246
Residue number A
261
Residue number B
306
Peptide name
Contactin-2

Ligandability

Cysteine 261 of Contactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Contactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Contactin-2 between cysteines 61 and 111 (31 and 81 respectively in this structure).

Details

Redox score ?
82
PDB code
2om5
Structure name
n-terminal fragment of human tax1
Structure deposition date
2007-01-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q02246
Residue number A
61
Residue number B
111
Peptide name
Contactin-2

Ligandability

Cysteine 61 of Contactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 111 of Contactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Contactin-2 between cysteines 155 and 207 (125 and 177 respectively in this structure).

Details

Redox score ?
82
PDB code
2om5
Structure name
n-terminal fragment of human tax1
Structure deposition date
2007-01-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q02246
Residue number A
155
Residue number B
207
Peptide name
Contactin-2

Ligandability

Cysteine 155 of Contactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of Contactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Contactin-2 between cysteines 348 and 395 (318 and 365 respectively in this structure).

Details

Redox score ?
81
PDB code
2om5
Structure name
n-terminal fragment of human tax1
Structure deposition date
2007-01-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q02246
Residue number A
348
Residue number B
395
Peptide name
Contactin-2

Ligandability

Cysteine 348 of Contactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 395 of Contactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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