ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Growth hormone-releasing hormone receptor

Intramolecular
Cysteine 78 and cysteine 112
Cysteine 202 and cysteine 272
Cysteine 55 and cysteine 96
Cysteine 41 and cysteine 64
A redox-regulated disulphide may form within Growth hormone-releasing hormone receptor between cysteines 78 and 112.

Details

Redox score ?
85
PDB code
2xdg
Structure name
crystal structure of the extracellular domain of human growth hormone releasing hormone receptor
Structure deposition date
2010-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q02643
Residue number A
78
Residue number B
112
Peptide name
Growth hormone-releasing hormone receptor

Ligandability

Cysteine 78 of Growth hormone-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of Growth hormone-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth hormone-releasing hormone receptor between cysteines 202 and 272.

Details

Redox score ?
85
PDB code
7cz5
Structure name
cryo-em structure of the human growth hormone-releasing hormone receptor-gs protein complex
Structure deposition date
2020-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q02643
Residue number A
202
Residue number B
272
Peptide name
Growth hormone-releasing hormone receptor

Ligandability

Cysteine 202 of Growth hormone-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Growth hormone-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth hormone-releasing hormone receptor between cysteines 55 and 96.

Details

Redox score ?
84
PDB code
2xdg
Structure name
crystal structure of the extracellular domain of human growth hormone releasing hormone receptor
Structure deposition date
2010-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q02643
Residue number A
55
Residue number B
96
Peptide name
Growth hormone-releasing hormone receptor

Ligandability

Cysteine 55 of Growth hormone-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Growth hormone-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth hormone-releasing hormone receptor between cysteines 41 and 64.

Details

Redox score ?
82
PDB code
2xdg
Structure name
crystal structure of the extracellular domain of human growth hormone releasing hormone receptor
Structure deposition date
2010-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q02643
Residue number A
41
Residue number B
64
Peptide name
Growth hormone-releasing hormone receptor

Ligandability

Cysteine 41 of Growth hormone-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Growth hormone-releasing hormone receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: