ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Intermolecular
Cysteine 235 and cysteine 235
Intramolecular
Cysteine 372 and cysteine 381
Cysteine 100 and cysteine 172
Cysteine 59 and cysteine 413
Cysteine 151 and cysteine 199
A redox-regulated disulphide may form between two units of Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase at cysteines 235 and 235.

Details

Redox score ?
85
PDB code
2gak
Structure name
x-ray crystal structure of murine leukocyte-type core 2 b1,6-n- acetylglucosaminyltransferase (c2gnt-l)
Structure deposition date
2006-03-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide A name
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Peptide B name
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Peptide A accession
Q09324
Peptide B accession
Q09324
Peptide A residue number
235
Peptide B residue number
235

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase between cysteines 372 and 381.

Details

Redox score ?
84
PDB code
2gak
Structure name
x-ray crystal structure of murine leukocyte-type core 2 b1,6-n- acetylglucosaminyltransferase (c2gnt-l)
Structure deposition date
2006-03-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q09324
Residue number A
372
Residue number B
381
Peptide name
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Ligandability

Cysteine 372 of Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 381 of Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase between cysteines 100 and 172.

Details

Redox score ?
83
PDB code
2gam
Structure name
x-ray crystal structure of murine leukocyte-type core 2 b1,6-n- acetylglucosaminyltransferase (c2gnt-l) in complex with galb1,3galnac
Structure deposition date
2006-03-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
17
Peptide accession
Q09324
Residue number A
100
Residue number B
172
Peptide name
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Ligandability

Cysteine 100 of Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase between cysteines 59 and 413.

Details

Redox score ?
76
PDB code
2gam
Structure name
x-ray crystal structure of murine leukocyte-type core 2 b1,6-n- acetylglucosaminyltransferase (c2gnt-l) in complex with galb1,3galnac
Structure deposition date
2006-03-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
48
Peptide accession
Q09324
Residue number A
59
Residue number B
413
Peptide name
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Ligandability

Cysteine 59 of Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 413 of Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase between cysteines 151 and 199.

Details

Redox score ?
73
PDB code
2gam
Structure name
x-ray crystal structure of murine leukocyte-type core 2 b1,6-n- acetylglucosaminyltransferase (c2gnt-l) in complex with galb1,3galnac
Structure deposition date
2006-03-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
100
Peptide accession
Q09324
Residue number A
151
Residue number B
199
Peptide name
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Ligandability

Cysteine 151 of Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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