ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DNA topoisomerase 2-beta

Intramolecular
Cysteine 387 and cysteine 413
Cysteine 883 and cysteine 1018 L
A redox-regulated disulphide may form within DNA topoisomerase 2-beta between cysteines 387 and 413 (382 and 408 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7qfn
Structure name
human topoisomerase ii beta atpase adp
Structure deposition date
2021-12-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
83
Peptide accession
Q02880
Residue number A
387
Residue number B
413
Peptide name
DNA topoisomerase 2-beta

Ligandability

Cysteine 387 of DNA topoisomerase 2-beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 413 of DNA topoisomerase 2-beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA topoisomerase 2-beta between cysteines 883 and 1018 (878 and 1013 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
4g0v
Structure name
human topoisomerase iibeta in complex with dna and mitoxantrone
Structure deposition date
2012-07-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
95
Peptide accession
Q02880
Residue number A
883
Residue number B
1018
Peptide name
DNA topoisomerase 2-beta

Ligandability

Cysteine 883 of DNA topoisomerase 2-beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1018 of DNA topoisomerase 2-beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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