ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Protein ENL

Intermolecular
Cysteine 99 and cysteine 99
Intramolecular
Cysteine 42 and cysteine 119 L
A redox-regulated disulphide may form between two units of Protein ENL at cysteines 99 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7e74
Structure name
crystal structure of enl yeats domain t3 mutant in complex with histone h3 acetylation at k27
Structure deposition date
2021-02-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
100
Peptide A name
Protein ENL
Peptide B name
Protein ENL
Peptide A accession
Q03111
Peptide B accession
Q03111
Peptide A residue number
99
Peptide B residue number
99

Ligandability

A redox-regulated disulphide may form within Protein ENL between cysteines 42 and 119 (42 and 122 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7x8f
Structure name
crystal structure of enl t4 mutant yeats domain in complex with histone h3 acetylation at k27
Structure deposition date
2022-03-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
42
Minimum pKa ?
10
% buried
12
Peptide accession
Q03111
Residue number A
42
Residue number B
119
Peptide name
Protein ENL

Ligandability

Cysteine 42 of Protein ENL

Cysteine 119 of Protein ENL

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