a tool for identifying drug-targetable redox-active disulphides

Caveolin-1

Intermolecular

Cysteine 133 and cysteine 143

A redox-regulated disulphide may form between two units of Caveolin-1 at cysteines 133 and 143.

Details

Redox score ?

66

PDB code

Structure name

cryoem structure of the caveolin-1 8s complex

Structure deposition date

2021-09-26

Thiol separation (Å)

6

Half-sphere exposure sum ?

47

Minimum pK_a ?

9

% buried

8

Peptide A name

Caveolin-1

Peptide B name

Caveolin-1

Peptide A accession

Peptide B accession

Peptide A residue number

133

Peptide B residue number

143

Ligandability

Cysteine 133 of Caveolin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of Caveolin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: