ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rod outer segment membrane protein 1

Intermolecular
Cysteine 222 of Peripherin-2 and cysteine 217
Cysteine 214 of Peripherin-2 and cysteine 217
Cysteine 222 of Peripherin-2 and cysteine 225
Cysteine 214 of Peripherin-2 and cysteine 225
A redox-regulated disulphide may form between cysteine 222 of Peripherin-2 and cysteine 217 of Rod outer segment membrane protein 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7zw1
Structure name
human prph2-rom1 hetero-dimer
Structure deposition date
2022-05-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide A name
Peripherin-2
Peptide B name
Rod outer segment membrane protein 1
Peptide A accession
P23942
Peptide B accession
Q03395
Peptide A residue number
222
Peptide B residue number
217

Ligandability

Cysteine 222 of Peripherin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Rod outer segment membrane protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 214 of Peripherin-2 and cysteine 217 of Rod outer segment membrane protein 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7zw1
Structure name
human prph2-rom1 hetero-dimer
Structure deposition date
2022-05-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide A name
Peripherin-2
Peptide B name
Rod outer segment membrane protein 1
Peptide A accession
P23942
Peptide B accession
Q03395
Peptide A residue number
214
Peptide B residue number
217

Ligandability

Cysteine 214 of Peripherin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Rod outer segment membrane protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 222 of Peripherin-2 and cysteine 225 of Rod outer segment membrane protein 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7zw1
Structure name
human prph2-rom1 hetero-dimer
Structure deposition date
2022-05-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Peripherin-2
Peptide B name
Rod outer segment membrane protein 1
Peptide A accession
P23942
Peptide B accession
Q03395
Peptide A residue number
222
Peptide B residue number
225

Ligandability

Cysteine 222 of Peripherin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 225 of Rod outer segment membrane protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 214 of Peripherin-2 and cysteine 225 of Rod outer segment membrane protein 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7zw1
Structure name
human prph2-rom1 hetero-dimer
Structure deposition date
2022-05-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
Peripherin-2
Peptide B name
Rod outer segment membrane protein 1
Peptide A accession
P23942
Peptide B accession
Q03395
Peptide A residue number
214
Peptide B residue number
225

Ligandability

Cysteine 214 of Peripherin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 225 of Rod outer segment membrane protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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