ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DNA excision repair protein ERCC-6

Intermolecular
Cysteine 178 of DNA excision repair protein ERCC-8 and cysteine 730
Intramolecular
Cysteine 730 and cysteine 732
Cysteine 766 and cysteine 806
A redox-regulated disulphide may form between cysteine 178 of DNA excision repair protein ERCC-8 and cysteine 730 of DNA excision repair protein ERCC-6. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7opc
Structure name
pol ii-csb-crl4csa-uvssa-spt6-paf (structure 4)
Structure deposition date
2021-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
86
Peptide A name
DNA excision repair protein ERCC-8
Peptide B name
DNA excision repair protein ERCC-6
Peptide A accession
Q13216
Peptide B accession
Q03468
Peptide A residue number
178
Peptide B residue number
730

Ligandability

Cysteine 178 of DNA excision repair protein ERCC-8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 730 of DNA excision repair protein ERCC-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA excision repair protein ERCC-6 between cysteines 730 and 732. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7oop
Structure name
pol ii-csb-csa-ddb1-uvssa-paf-spt6 (structure 3)
Structure deposition date
2021-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
53
Peptide accession
Q03468
Residue number A
730
Residue number B
732
Peptide name
DNA excision repair protein ERCC-6

Ligandability

Cysteine 730 of DNA excision repair protein ERCC-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 732 of DNA excision repair protein ERCC-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA excision repair protein ERCC-6 between cysteines 766 and 806. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7oob
Structure name
pol ii-csb-csa-ddb1-uvssa-adpbef3 (structure2)
Structure deposition date
2021-05-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
95
Peptide accession
Q03468
Residue number A
766
Residue number B
806
Peptide name
DNA excision repair protein ERCC-6

Ligandability

Cysteine 766 of DNA excision repair protein ERCC-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 806 of DNA excision repair protein ERCC-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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