ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

1,4-alpha-glucan-branching enzyme

Intramolecular
Cysteine 81 and cysteine 88 L
Cysteine 421 and cysteine 473
A redox-regulated disulphide may form within 1,4-alpha-glucan-branching enzyme between cysteines 81 and 88. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5clw
Structure name
crystal structure of human glycogen branching enzyme (gbe1) in complex with maltoheptaose
Structure deposition date
2015-07-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
56
Peptide accession
Q04446
Residue number A
81
Residue number B
88
Peptide name
1,4-alpha-glucan-branching enzyme

Ligandability

Cysteine 81 of 1,4-alpha-glucan-branching enzyme

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 88 of 1,4-alpha-glucan-branching enzyme

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1,4-alpha-glucan-branching enzyme between cysteines 421 and 473. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4bzy
Structure name
crystal structure of human glycogen branching enzyme (gbe1)
Structure deposition date
2013-07-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
82
Peptide accession
Q04446
Residue number A
421
Residue number B
473
Peptide name
1,4-alpha-glucan-branching enzyme

Ligandability

Cysteine 421 of 1,4-alpha-glucan-branching enzyme

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 473 of 1,4-alpha-glucan-branching enzyme

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: