Hepatocyte growth factor activator
Intermolecular
Cysteine 521 and cysteine 394
Cysteine 448 and cysteine 259 of Kunitz-type protease inhibitor 1
Cysteine 448 and cysteine 283 of Kunitz-type protease inhibitor 1
Cysteine 432 and cysteine 259 of Kunitz-type protease inhibitor 1
Intramolecular
Cysteine 594 and cysteine 448
Cysteine 594 and cysteine 521
Cysteine 594 and cysteine 604
Cysteine 535 and cysteine 604
Cysteine 440 and cysteine 510
Cysteine 567 and cysteine 583
More...Cysteine 594 and cysteine 622
Cysteine 432 and cysteine 448
Cysteine 589 and cysteine 604
Cysteine 589 and cysteine 594
Cysteine 589 and cysteine 521
3k2u A 122 B 393
A redox-regulated disulphide may form between two units of Hepatocyte growth factor activator at cysteines 521 and 394 (122 and 393 respectively in this structure).
Details
Redox score ?
82
PDB code
3k2u
Structure name
crystal structure of hgfa in complex with the allosteric inhibitory antibody fab40
Structure deposition date
2009-09-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide A name
Hepatocyte growth factor activator
Peptide B name
Hepatocyte growth factor activator
Peptide A accession
Q04756
Peptide B accession
Q04756
Peptide A residue number
521
Peptide B residue number
394
Ligandability
Cysteine 521 of Hepatocyte growth factor activator
Cysteine 394 of Hepatocyte growth factor activator
1yc0 A 448 I 259
A redox-regulated disulphide may form between cysteine 448 of Hepatocyte growth factor activator and cysteine 259 of Kunitz-type protease inhibitor 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
1yc0
Structure name
short form hgfa with first kunitz domain from hai-1
Structure deposition date
2004-12-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide A name
Hepatocyte growth factor activator
Peptide B name
Kunitz-type protease inhibitor 1
Peptide A accession
Q04756
Peptide B accession
O43278
Peptide A residue number
448
Peptide B residue number
259
Ligandability
Cysteine 448 of Hepatocyte growth factor activator
Cysteine 259 of Kunitz-type protease inhibitor 1
1yc0 A 448 I 283
A redox-regulated disulphide may form between cysteine 448 of Hepatocyte growth factor activator and cysteine 283 of Kunitz-type protease inhibitor 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
1yc0
Structure name
short form hgfa with first kunitz domain from hai-1
Structure deposition date
2004-12-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide A name
Hepatocyte growth factor activator
Peptide B name
Kunitz-type protease inhibitor 1
Peptide A accession
Q04756
Peptide B accession
O43278
Peptide A residue number
448
Peptide B residue number
283
Ligandability
Cysteine 448 of Hepatocyte growth factor activator
Cysteine 283 of Kunitz-type protease inhibitor 1
1yc0 A 432 I 259
A redox-regulated disulphide may form between cysteine 432 of Hepatocyte growth factor activator and cysteine 259 of Kunitz-type protease inhibitor 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
1yc0
Structure name
short form hgfa with first kunitz domain from hai-1
Structure deposition date
2004-12-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
99
Minimum pKa ?
nan
% buried
nan
Peptide A name
Hepatocyte growth factor activator
Peptide B name
Kunitz-type protease inhibitor 1
Peptide A accession
Q04756
Peptide B accession
O43278
Peptide A residue number
432
Peptide B residue number
259
Ligandability
Cysteine 432 of Hepatocyte growth factor activator
Cysteine 259 of Kunitz-type protease inhibitor 1
2wub C 191 C 220
A redox-regulated disulphide may form within Hepatocyte growth factor activator between cysteines 594 and 448 (191 and 220 respectively in this structure).
Details
Redox score ?
86
PDB code
2wub
Structure name
crystal structure of hgfa in complex with the allosteric non- inhibitory antibody fab40
Structure deposition date
2009-10-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04756
Residue number A
594
Residue number B
448
Peptide name
Hepatocyte growth factor activator
Ligandability
Cysteine 594 of Hepatocyte growth factor activator
Cysteine 448 of Hepatocyte growth factor activator
Uncertain whether structure cysteine 220 has been assigned to correct residue.
3k2u A 191 A 219
A redox-regulated disulphide may form within Hepatocyte growth factor activator between cysteines 594 and 521 (191 and 219 respectively in this structure).
Details
Redox score ?
86
PDB code
3k2u
Structure name
crystal structure of hgfa in complex with the allosteric inhibitory antibody fab40
Structure deposition date
2009-09-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04756
Residue number A
594
Residue number B
521
Peptide name
Hepatocyte growth factor activator
Ligandability
Cysteine 594 of Hepatocyte growth factor activator
Cysteine 521 of Hepatocyte growth factor activator
2wub A 191 A 220
A redox-regulated disulphide may form within Hepatocyte growth factor activator between cysteines 594 and 604 (191 and 220 respectively in this structure).
Details
Redox score ?
86
PDB code
2wub
Structure name
crystal structure of hgfa in complex with the allosteric non- inhibitory antibody fab40
Structure deposition date
2009-10-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04756
Residue number A
594
Residue number B
604
Peptide name
Hepatocyte growth factor activator
Ligandability
Cysteine 594 of Hepatocyte growth factor activator
Cysteine 604 of Hepatocyte growth factor activator
2wub C 136 C 201
A redox-regulated disulphide may form within Hepatocyte growth factor activator between cysteines 535 and 604 (136 and 201 respectively in this structure).
Details
Redox score ?
85
PDB code
2wub
Structure name
crystal structure of hgfa in complex with the allosteric non- inhibitory antibody fab40
Structure deposition date
2009-10-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04756
Residue number A
535
Residue number B
604
Peptide name
Hepatocyte growth factor activator
Ligandability
Cysteine 535 of Hepatocyte growth factor activator
Cysteine 604 of Hepatocyte growth factor activator
2wub A 50 A 111
A redox-regulated disulphide may form within Hepatocyte growth factor activator between cysteines 440 and 510 (50 and 111 respectively in this structure).
Details
Redox score ?
84
PDB code
2wub
Structure name
crystal structure of hgfa in complex with the allosteric non- inhibitory antibody fab40
Structure deposition date
2009-10-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04756
Residue number A
440
Residue number B
510
Peptide name
Hepatocyte growth factor activator
Ligandability
Cysteine 440 of Hepatocyte growth factor activator
Cysteine 510 of Hepatocyte growth factor activator
2wub C 168 C 182
A redox-regulated disulphide may form within Hepatocyte growth factor activator between cysteines 567 and 583 (168 and 182 respectively in this structure).
Details
Redox score ?
82
PDB code
2wub
Structure name
crystal structure of hgfa in complex with the allosteric non- inhibitory antibody fab40
Structure deposition date
2009-10-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04756
Residue number A
567
Residue number B
583
Peptide name
Hepatocyte growth factor activator
Ligandability
Cysteine 567 of Hepatocyte growth factor activator
Cysteine 583 of Hepatocyte growth factor activator
2wuc A 191 A 220
A redox-regulated disulphide may form within Hepatocyte growth factor activator between cysteines 594 and 622 (191 and 220 respectively in this structure).
Details
Redox score ?
78
PDB code
2wuc
Structure name
crystal structure of hgfa in complex with the allosteric non- inhibitory antibody fab40
Structure deposition date
2009-10-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04756
Residue number A
594
Residue number B
622
Peptide name
Hepatocyte growth factor activator
Ligandability
Cysteine 594 of Hepatocyte growth factor activator
Cysteine 622 of Hepatocyte growth factor activator
2wuc A 42 A 58
A redox-regulated disulphide may form within Hepatocyte growth factor activator between cysteines 432 and 448 (42 and 58 respectively in this structure).
Details
Redox score ?
78
PDB code
2wuc
Structure name
crystal structure of hgfa in complex with the allosteric non- inhibitory antibody fab40
Structure deposition date
2009-10-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04756
Residue number A
432
Residue number B
448
Peptide name
Hepatocyte growth factor activator
Ligandability
Cysteine 432 of Hepatocyte growth factor activator
Cysteine 448 of Hepatocyte growth factor activator
2wub A 187 A 220
A redox-regulated disulphide may form within Hepatocyte growth factor activator between cysteines 589 and 604 (187 and 220 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
2wub
Structure name
crystal structure of hgfa in complex with the allosteric non- inhibitory antibody fab40
Structure deposition date
2009-10-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
nan
Peptide accession
Q04756
Residue number A
589
Residue number B
604
Peptide name
Hepatocyte growth factor activator
Ligandability
Cysteine 589 of Hepatocyte growth factor activator
Cysteine 604 of Hepatocyte growth factor activator
2wub A 187 A 191
A redox-regulated disulphide may form within Hepatocyte growth factor activator between cysteines 589 and 594 (187 and 191 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
2wub
Structure name
crystal structure of hgfa in complex with the allosteric non- inhibitory antibody fab40
Structure deposition date
2009-10-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
nan
Peptide accession
Q04756
Residue number A
589
Residue number B
594
Peptide name
Hepatocyte growth factor activator
Ligandability
Cysteine 589 of Hepatocyte growth factor activator
Cysteine 594 of Hepatocyte growth factor activator
3k2u A 187 A 219
A redox-regulated disulphide may form within Hepatocyte growth factor activator between cysteines 589 and 521 (187 and 219 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3k2u
Structure name
crystal structure of hgfa in complex with the allosteric inhibitory antibody fab40
Structure deposition date
2009-09-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide accession
Q04756
Residue number A
589
Residue number B
521
Peptide name
Hepatocyte growth factor activator
Ligandability
Cysteine 589 of Hepatocyte growth factor activator
Cysteine 521 of Hepatocyte growth factor activator
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