Protein kinase C theta type
Intramolecular
Cysteine 190 and cysteine 209
Cysteine 262 and cysteine 281
Cysteine 262 and cysteine 265
Cysteine 173 and cysteine 176
Cysteine 173 and cysteine 201
Cysteine 245 and cysteine 248
Cysteine 190 and cysteine 193
Cysteine 245 and cysteine 273
Cysteine 193 and cysteine 209
Cysteine 248 and cysteine 273
More...Cysteine 265 and cysteine 281
Cysteine 176 and cysteine 201
Cysteine 159 and cysteine 209
Cysteine 159 and cysteine 190
Cysteine 17 and cysteine 20
Cysteine 159 and cysteine 193
Cysteine 14 and cysteine 20
Cysteine 14 and cysteine 17
Cysteine 424 and cysteine 540
Cysteine 14 and cysteine 29
Cysteine 526 and cysteine 540
Cysteine 424 and cysteine 526
2enn A 190 A 209
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 190 and 209.
Details
Redox score ?
91
PDB code
2enn
Structure name
solution structure of the first c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
5
% buried
5
Peptide accession
Q04759
Residue number A
190
Residue number B
209
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 190 of Protein kinase C theta type
Cysteine 209 of Protein kinase C theta type
2enz A 262 A 281
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 262 and 281.
Details
Redox score ?
91
PDB code
2enz
Structure name
solution structure of the second c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
5
% buried
4
Peptide accession
Q04759
Residue number A
262
Residue number B
281
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 262 of Protein kinase C theta type
Cysteine 281 of Protein kinase C theta type
2enz A 262 A 265
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 262 and 265.
Details
Redox score ?
90
PDB code
2enz
Structure name
solution structure of the second c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
5
% buried
4
Peptide accession
Q04759
Residue number A
262
Residue number B
265
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 262 of Protein kinase C theta type
Cysteine 265 of Protein kinase C theta type
2enn A 173 A 176
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 173 and 176.
Details
Redox score ?
89
PDB code
2enn
Structure name
solution structure of the first c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
5
% buried
12
Peptide accession
Q04759
Residue number A
173
Residue number B
176
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 173 of Protein kinase C theta type
Cysteine 176 of Protein kinase C theta type
2enn A 173 A 201
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 173 and 201.
Details
Redox score ?
89
PDB code
2enn
Structure name
solution structure of the first c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
5
% buried
16
Peptide accession
Q04759
Residue number A
173
Residue number B
201
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 173 of Protein kinase C theta type
Cysteine 201 of Protein kinase C theta type
2enz A 245 A 248
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 245 and 248.
Details
Redox score ?
89
PDB code
2enz
Structure name
solution structure of the second c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
5
% buried
6
Peptide accession
Q04759
Residue number A
245
Residue number B
248
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 245 of Protein kinase C theta type
Cysteine 248 of Protein kinase C theta type
2enn A 190 A 193
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 190 and 193.
Details
Redox score ?
88
PDB code
2enn
Structure name
solution structure of the first c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
5
% buried
12
Peptide accession
Q04759
Residue number A
190
Residue number B
193
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 190 of Protein kinase C theta type
Cysteine 193 of Protein kinase C theta type
2enz A 245 A 273
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 245 and 273.
Details
Redox score ?
87
PDB code
2enz
Structure name
solution structure of the second c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
5
% buried
6
Peptide accession
Q04759
Residue number A
245
Residue number B
273
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 245 of Protein kinase C theta type
Cysteine 273 of Protein kinase C theta type
2enn A 193 A 209
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 193 and 209.
Details
Redox score ?
83
PDB code
2enn
Structure name
solution structure of the first c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
7
Peptide accession
Q04759
Residue number A
193
Residue number B
209
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 193 of Protein kinase C theta type
Cysteine 209 of Protein kinase C theta type
2enz A 248 A 273
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 248 and 273.
Details
Redox score ?
82
PDB code
2enz
Structure name
solution structure of the second c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
8
% buried
0
Peptide accession
Q04759
Residue number A
248
Residue number B
273
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 248 of Protein kinase C theta type
Cysteine 273 of Protein kinase C theta type
2enz A 265 A 281
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 265 and 281.
Details
Redox score ?
82
PDB code
2enz
Structure name
solution structure of the second c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
0
Peptide accession
Q04759
Residue number A
265
Residue number B
281
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 265 of Protein kinase C theta type
Cysteine 281 of Protein kinase C theta type
2enn A 176 A 201
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 176 and 201.
Details
Redox score ?
80
PDB code
2enn
Structure name
solution structure of the first c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
4
Peptide accession
Q04759
Residue number A
176
Residue number B
201
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 176 of Protein kinase C theta type
Cysteine 201 of Protein kinase C theta type
2enn A 159 A 209
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 159 and 209.
Details
Redox score ?
74
PDB code
2enn
Structure name
solution structure of the first c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
0
Peptide accession
Q04759
Residue number A
159
Residue number B
209
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 159 of Protein kinase C theta type
Cysteine 209 of Protein kinase C theta type
2enn A 159 A 190
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 159 and 190.
Details
Redox score ?
67
PDB code
2enn
Structure name
solution structure of the first c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
5
% buried
5
Peptide accession
Q04759
Residue number A
159
Residue number B
190
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 159 of Protein kinase C theta type
Cysteine 190 of Protein kinase C theta type
2enj A 17 A 20
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 17 and 20. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
2enj
Structure name
solution structure of the c2 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
15
Minimum pKa ?
9
% buried
0
Peptide accession
Q04759
Residue number A
17
Residue number B
20
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 17 of Protein kinase C theta type
Cysteine 20 of Protein kinase C theta type
2enn A 159 A 193
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 159 and 193. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
2enn
Structure name
solution structure of the first c1 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
7
Peptide accession
Q04759
Residue number A
159
Residue number B
193
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 159 of Protein kinase C theta type
Cysteine 193 of Protein kinase C theta type
2enj A 14 A 20
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 14 and 20. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
2enj
Structure name
solution structure of the c2 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
28
Minimum pKa ?
9
% buried
5
Peptide accession
Q04759
Residue number A
14
Residue number B
20
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 14 of Protein kinase C theta type
Cysteine 20 of Protein kinase C theta type
2enj A 14 A 17
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 14 and 17. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
2enj
Structure name
solution structure of the c2 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
29
Minimum pKa ?
9
% buried
5
Peptide accession
Q04759
Residue number A
14
Residue number B
17
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 14 of Protein kinase C theta type
Cysteine 17 of Protein kinase C theta type
4ra5 A 424 A 540
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 424 and 540. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4ra5
Structure name
human protein kinase c theta in complex with ligand compound 11a (6- [(1,3-dimethyl-azetidin-3-yl)-methyl-amino]-4(r)-methyl-7-phenyl-2, 10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one)
Structure deposition date
2014-09-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
61
Peptide accession
Q04759
Residue number A
424
Residue number B
540
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 424 of Protein kinase C theta type
Cysteine 540 of Protein kinase C theta type
2enj A 14 A 29
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 14 and 29. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
2enj
Structure name
solution structure of the c2 domain from human protein kinase c theta
Structure deposition date
2007-03-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
35
Peptide accession
Q04759
Residue number A
14
Residue number B
29
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 14 of Protein kinase C theta type
Cysteine 29 of Protein kinase C theta type
4ra5 A 526 A 540
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 526 and 540. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
4ra5
Structure name
human protein kinase c theta in complex with ligand compound 11a (6- [(1,3-dimethyl-azetidin-3-yl)-methyl-amino]-4(r)-methyl-7-phenyl-2, 10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one)
Structure deposition date
2014-09-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
83
Peptide accession
Q04759
Residue number A
526
Residue number B
540
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 526 of Protein kinase C theta type
Cysteine 540 of Protein kinase C theta type
5f9e A 424 A 526
A redox-regulated disulphide may form within Protein kinase C theta type between cysteines 424 and 526. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
5f9e
Structure name
structure of protein kinase c theta with compound 10: 2,2-dimethyl-7- (2-oxidanylidene-3~{h}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)- 3~{h}-quinazolin-4-one
Structure deposition date
2015-12-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
78
Peptide accession
Q04759
Residue number A
424
Residue number B
526
Peptide name
Protein kinase C theta type
Ligandability
Cysteine 424 of Protein kinase C theta type
Cysteine 526 of Protein kinase C theta type
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