a tool for identifying drug-targetable redox-active disulphides

Lactoylglutathione lyase

Intramolecular

Cysteine 19 and cysteine 20

A redox-regulated disulphide may form within Lactoylglutathione lyase between cysteines 19 and 20 (18 and 19 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

56

PDB code

Structure name

human glyoxalase i (with c-ter his tag) in glycerol-bound form

Structure deposition date

2022-02-03

Thiol separation (Å)

7

Half-sphere exposure sum ?

55

Minimum pK_a ?

10

% buried

42

Peptide accession

Residue number A

19

Residue number B

20

Peptide name

Lactoylglutathione lyase

Ligandability

Cysteine 19 of Lactoylglutathione lyase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 20 of Lactoylglutathione lyase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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