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a tool for identifying drug-targetable redox-active disulphides

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Macrophage-stimulating protein receptor

Intramolecular
Cysteine 527 and cysteine 545
Cysteine 616 and cysteine 640
Cysteine 536 and cysteine 552
Cysteine 548 and cysteine 558
Cysteine 29 and cysteine 590
Cysteine 386 and cysteine 422
Cysteine 107 and cysteine 162
Cysteine 385 and cysteine 407
Cysteine 101 and cysteine 104
Cysteine 533 and cysteine 567
More...
Cysteine 174 and cysteine 177
Cysteine 300 and cysteine 367
Cysteine 135 and cysteine 143
Cysteine 385 and cysteine 422
Cysteine 385 and cysteine 386
Cysteine 545 and cysteine 552
Cysteine 527 and cysteine 552
Cysteine 407 and cysteine 422
Cysteine 536 and cysteine 545
Cysteine 527 and cysteine 536
Cysteine 533 and cysteine 536
Cysteine 386 and cysteine 407
Cysteine 536 and cysteine 567
Cysteine 104 and cysteine 107
Cysteine 536 and cysteine 548
Cysteine 536 and cysteine 558
Cysteine 533 and cysteine 552
Cysteine 548 and cysteine 552
Cysteine 101 and cysteine 107
Cysteine 552 and cysteine 558
Cysteine 552 and cysteine 567
Cysteine 527 and cysteine 558
Cysteine 104 and cysteine 162
Cysteine 101 and cysteine 162
Cysteine 527 and cysteine 548
Cysteine 545 and cysteine 548
Cysteine 143 and cysteine 174
Cysteine 143 and cysteine 177
Cysteine 143 and cysteine 162
A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 527 and 545.

Details

Redox score ?
86
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
527
Residue number B
545
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 527 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 545 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 616 and 640.

Details

Redox score ?
86
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
616
Residue number B
640
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 616 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 640 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 536 and 552.

Details

Redox score ?
85
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
536
Residue number B
552
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 536 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 552 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 548 and 558.

Details

Redox score ?
85
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
548
Residue number B
558
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 548 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 29 and 590.

Details

Redox score ?
85
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
29
Residue number B
590
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 29 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 590 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 386 and 422.

Details

Redox score ?
85
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
386
Residue number B
422
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 386 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 422 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 107 and 162.

Details

Redox score ?
84
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
107
Residue number B
162
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 107 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 385 and 407.

Details

Redox score ?
83
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
385
Residue number B
407
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 385 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 407 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 101 and 104.

Details

Redox score ?
83
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
101
Residue number B
104
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 101 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 533 and 567.

Details

Redox score ?
83
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
533
Residue number B
567
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 533 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 567 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 174 and 177.

Details

Redox score ?
80
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
174
Residue number B
177
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 174 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 300 and 367.

Details

Redox score ?
79
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
300
Residue number B
367
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 300 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 367 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 135 and 143.

Details

Redox score ?
77
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
135
Residue number B
143
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 135 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 385 and 422.

Details

Redox score ?
74
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
385
Residue number B
422
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 385 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 422 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 385 and 386.

Details

Redox score ?
71
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
385
Residue number B
386
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 385 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 386 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 545 and 552.

Details

Redox score ?
71
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
545
Residue number B
552
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 545 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 552 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 527 and 552.

Details

Redox score ?
70
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
527
Residue number B
552
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 527 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 552 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 407 and 422.

Details

Redox score ?
64
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
407
Residue number B
422
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 407 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 422 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 536 and 545.

Details

Redox score ?
62
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
536
Residue number B
545
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 536 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 545 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 527 and 536.

Details

Redox score ?
62
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
527
Residue number B
536
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 527 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 536 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 533 and 536.

Details

Redox score ?
60
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
533
Residue number B
536
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 533 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 536 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 386 and 407. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
386
Residue number B
407
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 386 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 407 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 536 and 567. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
536
Residue number B
567
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 536 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 567 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 104 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
104
Residue number B
107
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 104 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 536 and 548. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
536
Residue number B
548
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 536 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 548 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 536 and 558. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
536
Residue number B
558
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 536 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 533 and 552. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
533
Residue number B
552
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 533 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 552 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 548 and 552. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
548
Residue number B
552
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 548 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 552 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 101 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
101
Residue number B
107
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 101 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 552 and 558. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
552
Residue number B
558
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 552 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 552 and 567. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
552
Residue number B
567
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 552 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 567 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 527 and 558. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
527
Residue number B
558
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 527 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 104 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
104
Residue number B
162
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 104 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 101 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
101
Residue number B
162
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 101 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 527 and 548. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
527
Residue number B
548
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 527 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 548 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 545 and 548. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4fww
Structure name
crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
Structure deposition date
2012-07-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
545
Residue number B
548
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 545 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 548 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 143 and 174. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
143
Residue number B
174
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 143 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 143 and 177. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
143
Residue number B
177
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 143 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage-stimulating protein receptor between cysteines 143 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q04912
Residue number A
143
Residue number B
162
Peptide name
Macrophage-stimulating protein receptor

Ligandability

Cysteine 143 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Macrophage-stimulating protein receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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