ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cleavage stimulation factor subunit 1

Intramolecular
Cysteine 111 and cysteine 415
Cysteine 402 and cysteine 415
Cysteine 111 and cysteine 402
Cysteine 266 and cysteine 310
Cysteine 285 and cysteine 296
Cysteine 379 and cysteine 380
A redox-regulated disulphide may form within Cleavage stimulation factor subunit 1 between cysteines 111 and 415.

Details

Redox score ?
73
PDB code
6b3x
Structure name
crystal structure of cstf-50 in complex with cstf-77
Structure deposition date
2017-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
6
% buried
100
Peptide accession
Q05048
Residue number A
111
Residue number B
415
Peptide name
Cleavage stimulation factor subunit 1

Ligandability

Cysteine 111 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 415 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage stimulation factor subunit 1 between cysteines 402 and 415.

Details

Redox score ?
62
PDB code
6b3x
Structure name
crystal structure of cstf-50 in complex with cstf-77
Structure deposition date
2017-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
91
Minimum pKa ?
8
% buried
100
Peptide accession
Q05048
Residue number A
402
Residue number B
415
Peptide name
Cleavage stimulation factor subunit 1

Ligandability

Cysteine 402 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 415 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage stimulation factor subunit 1 between cysteines 111 and 402. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6b3x
Structure name
crystal structure of cstf-50 in complex with cstf-77
Structure deposition date
2017-09-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
6
% buried
100
Peptide accession
Q05048
Residue number A
111
Residue number B
402
Peptide name
Cleavage stimulation factor subunit 1

Ligandability

Cysteine 111 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 402 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage stimulation factor subunit 1 between cysteines 266 and 310. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6b3x
Structure name
crystal structure of cstf-50 in complex with cstf-77
Structure deposition date
2017-09-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
92
Minimum pKa ?
8
% buried
98
Peptide accession
Q05048
Residue number A
266
Residue number B
310
Peptide name
Cleavage stimulation factor subunit 1

Ligandability

Cysteine 266 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage stimulation factor subunit 1 between cysteines 285 and 296. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6b3x
Structure name
crystal structure of cstf-50 in complex with cstf-77
Structure deposition date
2017-09-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
50
Peptide accession
Q05048
Residue number A
285
Residue number B
296
Peptide name
Cleavage stimulation factor subunit 1

Ligandability

Cysteine 285 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage stimulation factor subunit 1 between cysteines 379 and 380. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6b3x
Structure name
crystal structure of cstf-50 in complex with cstf-77
Structure deposition date
2017-09-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
78
Peptide accession
Q05048
Residue number A
379
Residue number B
380
Peptide name
Cleavage stimulation factor subunit 1

Ligandability

Cysteine 379 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 380 of Cleavage stimulation factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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