Tyrosine-protein phosphatase non-receptor type 12
Intramolecular
Cysteine 133 and cysteine 143
Cysteine 231 and cysteine 235
Cysteine 133 and cysteine 231
Cysteine 143 and cysteine 228
Cysteine 143 and cysteine 231
Cysteine 231 and cysteine 242
Cysteine 228 and cysteine 242
5j8r C 133 C 143
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 12 between cysteines 133 and 143.
Details
Redox score ?
67
PDB code
5j8r
Structure name
crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 12 - k61r mutant
Structure deposition date
2016-04-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
92
Peptide accession
Q05209
Residue number A
133
Residue number B
143
Peptide name
Tyrosine-protein phosphatase non-receptor type 12
Ligandability
Cysteine 133 of Tyrosine-protein phosphatase non-receptor type 12
Cysteine 143 of Tyrosine-protein phosphatase non-receptor type 12
5j8r B 231 B 235
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 12 between cysteines 231 and 235. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
5j8r
Structure name
crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 12 - k61r mutant
Structure deposition date
2016-04-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
8
% buried
100
Peptide accession
Q05209
Residue number A
231
Residue number B
235
Peptide name
Tyrosine-protein phosphatase non-receptor type 12
Ligandability
Cysteine 231 of Tyrosine-protein phosphatase non-receptor type 12
Cysteine 235 of Tyrosine-protein phosphatase non-receptor type 12
5j8r A 133 A 231
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 12 between cysteines 133 and 231. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
5j8r
Structure name
crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 12 - k61r mutant
Structure deposition date
2016-04-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
99
Peptide accession
Q05209
Residue number A
133
Residue number B
231
Peptide name
Tyrosine-protein phosphatase non-receptor type 12
Ligandability
Cysteine 133 of Tyrosine-protein phosphatase non-receptor type 12
Cysteine 231 of Tyrosine-protein phosphatase non-receptor type 12
5hde A 143 A 228
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 12 between cysteines 143 and 228. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5hde
Structure name
crystal structure of ptpn12 catalytic domain
Structure deposition date
2016-01-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
6
% buried
100
Peptide accession
Q05209
Residue number A
143
Residue number B
228
Peptide name
Tyrosine-protein phosphatase non-receptor type 12
Ligandability
Cysteine 143 of Tyrosine-protein phosphatase non-receptor type 12
Cysteine 228 of Tyrosine-protein phosphatase non-receptor type 12
5j8r A 143 A 231
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 12 between cysteines 143 and 231. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
5j8r
Structure name
crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 12 - k61r mutant
Structure deposition date
2016-04-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
9
% buried
100
Peptide accession
Q05209
Residue number A
143
Residue number B
231
Peptide name
Tyrosine-protein phosphatase non-receptor type 12
Ligandability
Cysteine 143 of Tyrosine-protein phosphatase non-receptor type 12
Cysteine 231 of Tyrosine-protein phosphatase non-receptor type 12
5j8r B 231 B 242
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 12 between cysteines 231 and 242. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
5j8r
Structure name
crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 12 - k61r mutant
Structure deposition date
2016-04-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
91
Minimum pKa ?
8
% buried
100
Peptide accession
Q05209
Residue number A
231
Residue number B
242
Peptide name
Tyrosine-protein phosphatase non-receptor type 12
Ligandability
Cysteine 231 of Tyrosine-protein phosphatase non-receptor type 12
Cysteine 242 of Tyrosine-protein phosphatase non-receptor type 12
5j8r A 228 A 242
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 12 between cysteines 228 and 242. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
23
PDB code
5j8r
Structure name
crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 12 - k61r mutant
Structure deposition date
2016-04-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
93
Minimum pKa ?
13
% buried
100
Peptide accession
Q05209
Residue number A
228
Residue number B
242
Peptide name
Tyrosine-protein phosphatase non-receptor type 12
Ligandability
Cysteine 228 of Tyrosine-protein phosphatase non-receptor type 12
Cysteine 242 of Tyrosine-protein phosphatase non-receptor type 12
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