ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Elongation factor 1-alpha 2

Intramolecular
Cysteine 363 and cysteine 370
Cysteine 363 and cysteine 411
A redox-regulated disulphide may form within Elongation factor 1-alpha 2 between cysteines 363 and 370. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
8b6z
Structure name
cryoem structure of extended eef1a bound to the ribosome in the classical pre state
Structure deposition date
2022-09-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
88
Peptide accession
Q05639
Residue number A
363
Residue number B
370
Peptide name
Elongation factor 1-alpha 2

Ligandability

Cysteine 363 of Elongation factor 1-alpha 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 370 of Elongation factor 1-alpha 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Elongation factor 1-alpha 2 between cysteines 363 and 411. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
8b6z
Structure name
cryoem structure of extended eef1a bound to the ribosome in the classical pre state
Structure deposition date
2022-09-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
100
Peptide accession
Q05639
Residue number A
363
Residue number B
411
Peptide name
Elongation factor 1-alpha 2

Ligandability

Cysteine 363 of Elongation factor 1-alpha 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 411 of Elongation factor 1-alpha 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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