Protein kinase C delta type
Intramolecular
Cysteine 244 and cysteine 272
Cysteine 261 and cysteine 280
Cysteine 244 and cysteine 247
Cysteine 261 and cysteine 264
Cysteine 264 and cysteine 280
Cysteine 247 and cysteine 272
Cysteine 95 and cysteine 117
3uff A 244 A 272
A redox-regulated disulphide may form within Protein kinase C delta type between cysteines 244 and 272.
Details
Redox score ?
89
PDB code
3uff
Structure name
structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase cdelta
Structure deposition date
2011-11-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
5
% buried
6
Peptide accession
P28867
Residue number A
244
Residue number B
272
Peptide name
Protein kinase C delta type
Ligandability
Cysteine 244 of Protein kinase C delta type
Cysteine 272 of Protein kinase C delta type
3uff B 261 B 280
A redox-regulated disulphide may form within Protein kinase C delta type between cysteines 261 and 280.
Details
Redox score ?
87
PDB code
3uff
Structure name
structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase cdelta
Structure deposition date
2011-11-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
5
% buried
23
Peptide accession
P28867
Residue number A
261
Residue number B
280
Peptide name
Protein kinase C delta type
Ligandability
Cysteine 261 of Protein kinase C delta type
Cysteine 280 of Protein kinase C delta type
1ptq A 244 A 247
A redox-regulated disulphide may form within Protein kinase C delta type between cysteines 244 and 247.
Details
Redox score ?
87
PDB code
1ptq
Structure name
protein kinase c delta cys2 domain
Structure deposition date
1995-05-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
5
% buried
6
Peptide accession
P28867
Residue number A
244
Residue number B
247
Peptide name
Protein kinase C delta type
Ligandability
Cysteine 244 of Protein kinase C delta type
Cysteine 247 of Protein kinase C delta type
1ptq A 261 A 264
A redox-regulated disulphide may form within Protein kinase C delta type between cysteines 261 and 264.
Details
Redox score ?
86
PDB code
1ptq
Structure name
protein kinase c delta cys2 domain
Structure deposition date
1995-05-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
6
% buried
0
Peptide accession
P28867
Residue number A
261
Residue number B
264
Peptide name
Protein kinase C delta type
Ligandability
Cysteine 261 of Protein kinase C delta type
Cysteine 264 of Protein kinase C delta type
1ptr A 264 A 280
A redox-regulated disulphide may form within Protein kinase C delta type between cysteines 264 and 280.
Details
Redox score ?
85
PDB code
1ptr
Structure name
protein kinase c delta cys2 domain complexed with phorbol- 13-acetate
Structure deposition date
1995-05-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
0
Peptide accession
P28867
Residue number A
264
Residue number B
280
Peptide name
Protein kinase C delta type
Ligandability
Cysteine 264 of Protein kinase C delta type
Cysteine 280 of Protein kinase C delta type
3uey A 247 A 272
A redox-regulated disulphide may form within Protein kinase C delta type between cysteines 247 and 272.
Details
Redox score ?
82
PDB code
3uey
Structure name
structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase cdelta
Structure deposition date
2011-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
0
Peptide accession
P28867
Residue number A
247
Residue number B
272
Peptide name
Protein kinase C delta type
Ligandability
Cysteine 247 of Protein kinase C delta type
Cysteine 272 of Protein kinase C delta type
1bdy B 95 B 117
A redox-regulated disulphide may form within Protein kinase C delta type between cysteines 95 and 117. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1bdy
Structure name
c2 domain from protein kinase c delta
Structure deposition date
1998-05-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
60
Peptide accession
P09215
Residue number A
95
Residue number B
117
Peptide name
Protein kinase C delta type
Ligandability
Cysteine 95 of Protein kinase C delta type
Cysteine 117 of Protein kinase C delta type
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