ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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2-5A-dependent ribonuclease

Intramolecular
Cysteine 407 and cysteine 479
Cysteine 293 and cysteine 301
A redox-regulated disulphide may form within 2-5A-dependent ribonuclease between cysteines 407 and 479. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
4oav
Structure name
complete human rnase l in complex with 2-5a (5'-ppp heptamer), amppcp and rna substrate
Structure deposition date
2014-01-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
92
Peptide accession
Q05823
Residue number A
407
Residue number B
479
Peptide name
2-5A-dependent ribonuclease

Ligandability

Cysteine 407 of 2-5A-dependent ribonuclease

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 479 of 2-5A-dependent ribonuclease

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 2-5A-dependent ribonuclease between cysteines 293 and 301. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4oav
Structure name
complete human rnase l in complex with 2-5a (5'-ppp heptamer), amppcp and rna substrate
Structure deposition date
2014-01-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
51
Peptide accession
Q05823
Residue number A
293
Residue number B
301
Peptide name
2-5A-dependent ribonuclease

Ligandability

Cysteine 293 of 2-5A-dependent ribonuclease

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 301 of 2-5A-dependent ribonuclease

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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