ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zona pellucida sperm-binding protein 2

Intramolecular
Cysteine 84 and cysteine 102
Cysteine 613 and cysteine 623
Cysteine 51 and cysteine 134
Cysteine 559 and cysteine 627
Cysteine 538 and cysteine 608
A redox-regulated disulphide may form within Zona pellucida sperm-binding protein 2 between cysteines 84 and 102.

Details

Redox score ?
89
PDB code
5ii6
Structure name
crystal structure of the zp-n1 domain of mouse sperm receptor zp2 at 0
Structure deposition date
2016-03-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20239
Residue number A
84
Residue number B
102
Peptide name
Zona pellucida sperm-binding protein 2

Ligandability

Cysteine 84 of Zona pellucida sperm-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of Zona pellucida sperm-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zona pellucida sperm-binding protein 2 between cysteines 613 and 623.

Details

Redox score ?
85
PDB code
5bup
Structure name
crystal structure of the zp-c domain of mouse zp2
Structure deposition date
2015-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20239
Residue number A
613
Residue number B
623
Peptide name
Zona pellucida sperm-binding protein 2

Ligandability

Cysteine 613 of Zona pellucida sperm-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 623 of Zona pellucida sperm-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zona pellucida sperm-binding protein 2 between cysteines 51 and 134.

Details

Redox score ?
85
PDB code
5ii6
Structure name
crystal structure of the zp-n1 domain of mouse sperm receptor zp2 at 0
Structure deposition date
2016-03-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20239
Residue number A
51
Residue number B
134
Peptide name
Zona pellucida sperm-binding protein 2

Ligandability

Cysteine 51 of Zona pellucida sperm-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Zona pellucida sperm-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zona pellucida sperm-binding protein 2 between cysteines 559 and 627.

Details

Redox score ?
84
PDB code
5bup
Structure name
crystal structure of the zp-c domain of mouse zp2
Structure deposition date
2015-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20239
Residue number A
559
Residue number B
627
Peptide name
Zona pellucida sperm-binding protein 2

Ligandability

Cysteine 559 of Zona pellucida sperm-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 627 of Zona pellucida sperm-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zona pellucida sperm-binding protein 2 between cysteines 538 and 608.

Details

Redox score ?
82
PDB code
5bup
Structure name
crystal structure of the zp-c domain of mouse zp2
Structure deposition date
2015-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20239
Residue number A
538
Residue number B
608
Peptide name
Zona pellucida sperm-binding protein 2

Ligandability

Cysteine 538 of Zona pellucida sperm-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 608 of Zona pellucida sperm-binding protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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