ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Regenerating islet-derived protein 3-alpha

Intramolecular
Cysteine 40 and cysteine 51
Cysteine 146 and cysteine 163
Cysteine 68 and cysteine 171
Cysteine 51 and cysteine 171
A redox-regulated disulphide may form within Regenerating islet-derived protein 3-alpha between cysteines 40 and 51.

Details

Redox score ?
86
PDB code
4mth
Structure name
crystal structure of mature human regiiialpha
Structure deposition date
2013-09-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q06141
Residue number A
40
Residue number B
51
Peptide name
Regenerating islet-derived protein 3-alpha

Ligandability

Cysteine 40 of Regenerating islet-derived protein 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Regenerating islet-derived protein 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regenerating islet-derived protein 3-alpha between cysteines 146 and 163.

Details

Redox score ?
83
PDB code
4mth
Structure name
crystal structure of mature human regiiialpha
Structure deposition date
2013-09-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q06141
Residue number A
146
Residue number B
163
Peptide name
Regenerating islet-derived protein 3-alpha

Ligandability

Cysteine 146 of Regenerating islet-derived protein 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of Regenerating islet-derived protein 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regenerating islet-derived protein 3-alpha between cysteines 68 and 171.

Details

Redox score ?
82
PDB code
4mth
Structure name
crystal structure of mature human regiiialpha
Structure deposition date
2013-09-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q06141
Residue number A
68
Residue number B
171
Peptide name
Regenerating islet-derived protein 3-alpha

Ligandability

Cysteine 68 of Regenerating islet-derived protein 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 171 of Regenerating islet-derived protein 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regenerating islet-derived protein 3-alpha between cysteines 51 and 171 (13 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
2go0
Structure name
nmr solution structure of human pancreatitis-associated protein
Structure deposition date
2006-04-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q06141
Residue number A
51
Residue number B
171
Peptide name
Regenerating islet-derived protein 3-alpha

Ligandability

Cysteine 51 of Regenerating islet-derived protein 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 171 of Regenerating islet-derived protein 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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