ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Exosome complex component RRP45

Intramolecular
Cysteine 109 and cysteine 193
Cysteine 109 and cysteine 115
Cysteine 115 and cysteine 232
Cysteine 109 and cysteine 232
Cysteine 45 and cysteine 46
Cysteine 115 and cysteine 158
Cysteine 193 and cysteine 232
Cysteine 46 and cysteine 158
A redox-regulated disulphide may form within Exosome complex component RRP45 between cysteines 109 and 193.

Details

Redox score ?
66
PDB code
6d6q
Structure name
human nuclear exosome-mtr4 rna complex - overall reconstruction
Structure deposition date
2018-04-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
9
% buried
100
Peptide accession
Q06265
Residue number A
109
Residue number B
193
Peptide name
Exosome complex component RRP45

Ligandability

Cysteine 109 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 193 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP45 between cysteines 109 and 115. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
92
Peptide accession
Q86Y41
Residue number A
109
Residue number B
115
Peptide name
Exosome complex component RRP45

Ligandability

Cysteine 109 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP45 between cysteines 115 and 232. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
88
Peptide accession
Q86Y41
Residue number A
115
Residue number B
232
Peptide name
Exosome complex component RRP45

Ligandability

Cysteine 115 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP45 between cysteines 109 and 232. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
96
Peptide accession
Q86Y41
Residue number A
109
Residue number B
232
Peptide name
Exosome complex component RRP45

Ligandability

Cysteine 109 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP45 between cysteines 45 and 46. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2nn6
Structure name
structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40
Structure deposition date
2006-10-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
Q86Y41
Residue number A
45
Residue number B
46
Peptide name
Exosome complex component RRP45

Ligandability

Cysteine 45 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP45 between cysteines 115 and 158. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6d6r
Structure name
human nuclear exosome-mtr4 rna complex - composite map after focused reconstruction
Structure deposition date
2018-04-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
96
Peptide accession
Q06265
Residue number A
115
Residue number B
158
Peptide name
Exosome complex component RRP45

Ligandability

Cysteine 115 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP45 between cysteines 193 and 232. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
6d6r
Structure name
human nuclear exosome-mtr4 rna complex - composite map after focused reconstruction
Structure deposition date
2018-04-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
94
Minimum pKa ?
12
% buried
96
Peptide accession
Q06265
Residue number A
193
Residue number B
232
Peptide name
Exosome complex component RRP45

Ligandability

Cysteine 193 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP45 between cysteines 46 and 158. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
6d6q
Structure name
human nuclear exosome-mtr4 rna complex - overall reconstruction
Structure deposition date
2018-04-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
96
Peptide accession
Q06265
Residue number A
46
Residue number B
158
Peptide name
Exosome complex component RRP45

Ligandability

Cysteine 46 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of Exosome complex component RRP45

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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