ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Recombining binding protein suppressor of hairless

Intermolecular
Cysteine 100 and cysteine 63 of Mastermind-like protein 1
Cysteine 397 and cysteine 37 of Mastermind-like protein 1
Intramolecular
Cysteine 98 and cysteine 149
A redox-regulated disulphide may form between cysteine 100 of Recombining binding protein suppressor of hairless and cysteine 63 of Mastermind-like protein 1 (86 and 63 respectively in this structure).

Details

Redox score ?
76
PDB code
2f8x
Structure name
crystal structure of activated notch, csl and maml on hes-1 promoter dna sequence
Structure deposition date
2005-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
7
% buried
63
Peptide A name
Recombining binding protein suppressor of hairless
Peptide B name
Mastermind-like protein 1
Peptide A accession
Q06330
Peptide B accession
Q92585
Peptide A residue number
100
Peptide B residue number
63

Ligandability

Cysteine 100 of Recombining binding protein suppressor of hairless

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 63 of Mastermind-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 397 of Recombining binding protein suppressor of hairless and cysteine 37 of Mastermind-like protein 1 (383 and 37 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
2f8x
Structure name
crystal structure of activated notch, csl and maml on hes-1 promoter dna sequence
Structure deposition date
2005-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
92
Peptide A name
Recombining binding protein suppressor of hairless
Peptide B name
Mastermind-like protein 1
Peptide A accession
Q06330
Peptide B accession
Q92585
Peptide A residue number
397
Peptide B residue number
37

Ligandability

Cysteine 397 of Recombining binding protein suppressor of hairless

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Mastermind-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Recombining binding protein suppressor of hairless between cysteines 98 and 149. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6dks
Structure name
structure of the rbpj-sharp-dna repressor complex
Structure deposition date
2018-05-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
9
% buried
61
Peptide accession
P31266
Residue number A
98
Residue number B
149
Peptide name
Recombining binding protein suppressor of hairless

Ligandability

Cysteine 98 of Recombining binding protein suppressor of hairless

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Recombining binding protein suppressor of hairless

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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