ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tyrosine-protein kinase receptor TYRO3

Intramolecular
Cysteine 160 and cysteine 203
Cysteine 64 and cysteine 117
Cysteine 758 and cysteine 771
Cysteine 651 and cysteine 660
A redox-regulated disulphide may form within Tyrosine-protein kinase receptor TYRO3 between cysteines 160 and 203 (120 and 163 respectively in this structure).

Details

Redox score ?
83
PDB code
1rhf
Structure name
crystal structure of human tyro3-d1d2
Structure deposition date
2003-11-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q06418
Residue number A
160
Residue number B
203
Peptide name
Tyrosine-protein kinase receptor TYRO3

Ligandability

Cysteine 160 of Tyrosine-protein kinase receptor TYRO3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of Tyrosine-protein kinase receptor TYRO3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase receptor TYRO3 between cysteines 64 and 117 (24 and 77 respectively in this structure).

Details

Redox score ?
82
PDB code
1rhf
Structure name
crystal structure of human tyro3-d1d2
Structure deposition date
2003-11-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q06418
Residue number A
64
Residue number B
117
Peptide name
Tyrosine-protein kinase receptor TYRO3

Ligandability

Cysteine 64 of Tyrosine-protein kinase receptor TYRO3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of Tyrosine-protein kinase receptor TYRO3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase receptor TYRO3 between cysteines 758 and 771. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3qup
Structure name
inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase tyro3 (sky)
Structure deposition date
2011-02-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
60
Peptide accession
P55144
Residue number A
758
Residue number B
771
Peptide name
Tyrosine-protein kinase receptor TYRO3

Ligandability

Cysteine 758 of Tyrosine-protein kinase receptor TYRO3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 771 of Tyrosine-protein kinase receptor TYRO3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase receptor TYRO3 between cysteines 651 and 660. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
3qup
Structure name
inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase tyro3 (sky)
Structure deposition date
2011-02-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
85
Peptide accession
P55144
Residue number A
651
Residue number B
660
Peptide name
Tyrosine-protein kinase receptor TYRO3

Ligandability

Cysteine 651 of Tyrosine-protein kinase receptor TYRO3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 660 of Tyrosine-protein kinase receptor TYRO3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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