ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Voltage-dependent calcium channel gamma-1 subunit

Intramolecular
Cysteine 57 and cysteine 80
Cysteine 184 and cysteine 186
A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-1 subunit between cysteines 57 and 80.

Details

Redox score ?
85
PDB code
5gjv
Structure name
structure of the mammalian voltage-gated calcium channel cav1
Structure deposition date
2016-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P19518
Residue number A
57
Residue number B
80
Peptide name
Voltage-dependent calcium channel gamma-1 subunit

Ligandability

Cysteine 57 of Voltage-dependent calcium channel gamma-1 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 80 of Voltage-dependent calcium channel gamma-1 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-1 subunit between cysteines 184 and 186. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7jpw
Structure name
rabbit cav1
Structure deposition date
2020-08-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
34
Peptide accession
P19518
Residue number A
184
Residue number B
186
Peptide name
Voltage-dependent calcium channel gamma-1 subunit

Ligandability

Cysteine 184 of Voltage-dependent calcium channel gamma-1 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Voltage-dependent calcium channel gamma-1 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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