Amyloid beta precursor like protein 2
Intermolecular
Cysteine 310 and cysteine 360
Cysteine 319 and cysteine 343
Cysteine 310 and cysteine 335
Cysteine 310 and cysteine 356
Cysteine 68 of PRSS3 protein and cysteine 343
Cysteine 52 of PRSS3 protein and cysteine 343
Cysteine 68 of PRSS3 protein and cysteine 319
Cysteine 52 of PRSS3 protein and cysteine 319
Intramolecular
Cysteine 335 and cysteine 356
Cysteine 335 and cysteine 360
Cysteine 356 and cysteine 360
5jbt X 5 Y 55
A redox-regulated disulphide may form between two units of Amyloid beta precursor like protein 2 at cysteines 310 and 360 (5 and 55 respectively in this structure).
Details
Redox score ?
89
PDB code
5jbt
Structure name
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2)
Structure deposition date
2016-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Amyloid beta precursor like protein 2
Peptide B name
Amyloid beta precursor like protein 2
Peptide A accession
Q06481
Peptide B accession
Q06481
Peptide A residue number
310
Peptide B residue number
360
Ligandability
Cysteine 310 of Amyloid beta precursor like protein 2
Cysteine 360 of Amyloid beta precursor like protein 2
5jbt X 14 Y 38
A redox-regulated disulphide may form between two units of Amyloid beta precursor like protein 2 at cysteines 319 and 343 (14 and 38 respectively in this structure).
Details
Redox score ?
78
PDB code
5jbt
Structure name
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2)
Structure deposition date
2016-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
Amyloid beta precursor like protein 2
Peptide B name
Amyloid beta precursor like protein 2
Peptide A accession
Q06481
Peptide B accession
Q06481
Peptide A residue number
319
Peptide B residue number
343
Ligandability
Cysteine 319 of Amyloid beta precursor like protein 2
Cysteine 343 of Amyloid beta precursor like protein 2
5jbt X 5 Y 30
A redox-regulated disulphide may form between two units of Amyloid beta precursor like protein 2 at cysteines 310 and 335 (5 and 30 respectively in this structure).
Details
Redox score ?
62
PDB code
5jbt
Structure name
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2)
Structure deposition date
2016-04-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide A name
Amyloid beta precursor like protein 2
Peptide B name
Amyloid beta precursor like protein 2
Peptide A accession
Q06481
Peptide B accession
Q06481
Peptide A residue number
310
Peptide B residue number
335
Ligandability
Cysteine 310 of Amyloid beta precursor like protein 2
Cysteine 335 of Amyloid beta precursor like protein 2
5jbt X 5 Y 51
A redox-regulated disulphide may form between two units of Amyloid beta precursor like protein 2 at cysteines 310 and 356 (5 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
5jbt
Structure name
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2)
Structure deposition date
2016-04-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide A name
Amyloid beta precursor like protein 2
Peptide B name
Amyloid beta precursor like protein 2
Peptide A accession
Q06481
Peptide B accession
Q06481
Peptide A residue number
310
Peptide B residue number
356
Ligandability
Cysteine 310 of Amyloid beta precursor like protein 2
Cysteine 356 of Amyloid beta precursor like protein 2
5jbt A 58 Y 38
A redox-regulated disulphide may form between cysteine 68 of PRSS3 protein and cysteine 343 of Amyloid beta precursor like protein 2 (58 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5jbt
Structure name
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2)
Structure deposition date
2016-04-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
PRSS3 protein
Peptide B name
Amyloid beta precursor like protein 2
Peptide A accession
Q8N2U3
Peptide B accession
Q06481
Peptide A residue number
68
Peptide B residue number
343
Ligandability
Cysteine 68 of PRSS3 protein
Cysteine 343 of Amyloid beta precursor like protein 2
5jbt A 42 Y 38
A redox-regulated disulphide may form between cysteine 52 of PRSS3 protein and cysteine 343 of Amyloid beta precursor like protein 2 (42 and 38 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5jbt
Structure name
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2)
Structure deposition date
2016-04-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide A name
PRSS3 protein
Peptide B name
Amyloid beta precursor like protein 2
Peptide A accession
Q8N2U3
Peptide B accession
Q06481
Peptide A residue number
52
Peptide B residue number
343
Ligandability
Cysteine 52 of PRSS3 protein
Cysteine 343 of Amyloid beta precursor like protein 2
5jbt A 58 X 14
A redox-regulated disulphide may form between cysteine 68 of PRSS3 protein and cysteine 319 of Amyloid beta precursor like protein 2 (58 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5jbt
Structure name
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2)
Structure deposition date
2016-04-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide A name
PRSS3 protein
Peptide B name
Amyloid beta precursor like protein 2
Peptide A accession
Q8N2U3
Peptide B accession
Q06481
Peptide A residue number
68
Peptide B residue number
319
Ligandability
Cysteine 68 of PRSS3 protein
Cysteine 319 of Amyloid beta precursor like protein 2
5jbt A 42 X 14
A redox-regulated disulphide may form between cysteine 52 of PRSS3 protein and cysteine 319 of Amyloid beta precursor like protein 2 (42 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5jbt
Structure name
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2)
Structure deposition date
2016-04-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide A name
PRSS3 protein
Peptide B name
Amyloid beta precursor like protein 2
Peptide A accession
Q8N2U3
Peptide B accession
Q06481
Peptide A residue number
52
Peptide B residue number
319
Ligandability
Cysteine 52 of PRSS3 protein
Cysteine 319 of Amyloid beta precursor like protein 2
5jbt Y 30 Y 51
A redox-regulated disulphide may form within Amyloid beta precursor like protein 2 between cysteines 335 and 356 (30 and 51 respectively in this structure).
Details
Redox score ?
85
PDB code
5jbt
Structure name
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2)
Structure deposition date
2016-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q06481
Residue number A
335
Residue number B
356
Peptide name
Amyloid beta precursor like protein 2
Ligandability
Cysteine 335 of Amyloid beta precursor like protein 2
Cysteine 356 of Amyloid beta precursor like protein 2
5jbt Y 30 Y 55
A redox-regulated disulphide may form within Amyloid beta precursor like protein 2 between cysteines 335 and 360 (30 and 55 respectively in this structure).
Details
Redox score ?
76
PDB code
5jbt
Structure name
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2)
Structure deposition date
2016-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q06481
Residue number A
335
Residue number B
360
Peptide name
Amyloid beta precursor like protein 2
Ligandability
Cysteine 335 of Amyloid beta precursor like protein 2
Cysteine 360 of Amyloid beta precursor like protein 2
5jbt Y 51 Y 55
A redox-regulated disulphide may form within Amyloid beta precursor like protein 2 between cysteines 356 and 360 (51 and 55 respectively in this structure).
Details
Redox score ?
70
PDB code
5jbt
Structure name
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2)
Structure deposition date
2016-04-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q06481
Residue number A
356
Residue number B
360
Peptide name
Amyloid beta precursor like protein 2
Ligandability
Cysteine 356 of Amyloid beta precursor like protein 2
Cysteine 360 of Amyloid beta precursor like protein 2
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